Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2728030..2728546 Replicon chromosome
Accession NZ_CP079155
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC08_CMC432MC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KWY73_RS13240 Protein ID WP_004178374.1
Coordinates 2728262..2728546 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KWY73_RS13235 Protein ID WP_002886901.1
Coordinates 2728030..2728272 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY73_RS13220 (2724058) 2724058..2724798 + 741 WP_002886899.1 KDGP aldolase family protein -
KWY73_RS13225 (2724865) 2724865..2726019 + 1155 WP_004178372.1 lactonase family protein -
KWY73_RS13230 (2726042) 2726042..2727952 + 1911 WP_004178373.1 PRD domain-containing protein -
KWY73_RS13235 (2728030) 2728030..2728272 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWY73_RS13240 (2728262) 2728262..2728546 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY73_RS13245 (2728550) 2728550..2729014 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWY73_RS13250 (2729255) 2729255..2731393 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWY73_RS13255 (2731750) 2731750..2732493 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWY73_RS13260 (2732496) 2732496..2732669 - 174 WP_032408826.1 hypothetical protein -
KWY73_RS13265 (2732799) 2732799..2733062 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209369 WP_004178374.1 NZ_CP079155:2728262-2728546 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209369 NZ_CP104049:c1969252-1968968 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209369 WP_002886901.1 NZ_CP079155:2728030-2728272 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209369 NZ_CP104049:c1969490-1969242 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References