Detailed information of TA system TA209365

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 1348029..1348686
• Replicon: chromosome
• Accession: NZ_CP079155
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC08_CMC432MC

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KWY73_RS06545
• Protein ID: WP_004181233.1
• Coordinates: 1348029..1348439 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KWY73_RS06550
• Protein ID: WP_002916312.1
• Coordinates: 1348420..1348686 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY73_RS06525 (1344029)	1344029..1345762	-	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-
KWY73_RS06530 (1345768)	1345768..1346481	-	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KWY73_RS06535 (1346504)	1346504..1347400	-	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KWY73_RS06540 (1347501)	1347501..1348022	+	522	WP_004144730.1	flavodoxin FldB	-
KWY73_RS06545 (1348029)	1348029..1348439	-	411	WP_004181233.1	protein YgfX	Toxin
KWY73_RS06550 (1348420)	1348420..1348686	-	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KWY73_RS06555 (1348932)	1348932..1349915	+	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
KWY73_RS06560 (1350066)	1350066..1350725	-	660	WP_002916317.1	hemolysin III family protein	-
KWY73_RS06565 (1350889)	1350889..1351200	-	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KWY73_RS06570 (1351250)	1351250..1351978	+	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KWY73_RS06575 (1352097)	1352097..1353530	+	1434	WP_004181234.1	6-phospho-beta-glucosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T209365 WP_004181233.1 NZ_CP079155:c1348439-1348029 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209365 NZ_CP104049:195359-195844 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGGGACATGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCAACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGAAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT209365 WP_002916312.1 NZ_CP079155:c1348686-1348420 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209365 NZ_CP104049:195084-195371 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41