Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5050868..5052549 | Replicon | chromosome |
| Accession | NZ_CP079150 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC07_CMC432PC | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | KWY72_RS24475 | Protein ID | WP_004178299.1 |
| Coordinates | 5050868..5051785 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | KWY72_RS24480 | Protein ID | WP_004177809.1 |
| Coordinates | 5051791..5052549 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY72_RS24455 (5046174) | 5046174..5047694 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| KWY72_RS24460 (5047691) | 5047691..5048689 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| KWY72_RS24465 (5048720) | 5048720..5049661 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| KWY72_RS24470 (5049736) | 5049736..5050743 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| KWY72_RS24475 (5050868) | 5050868..5051785 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KWY72_RS24480 (5051791) | 5051791..5052549 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KWY72_RS24485 (5052635) | 5052635..5053363 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
| KWY72_RS24490 (5053636) | 5053636..5055783 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| KWY72_RS24495 (5056013) | 5056013..5056699 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T209351 WP_004178299.1 NZ_CP079150:c5051785-5050868 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T209351 NZ_CP104041:57870-58295 [Rhizobium leguminosarum bv. viciae]
GTGATTATCCTTGATACGAACGTCGTTTCCGAGGCGATGAAACCCGCGCCCGACGAAACCGTGAAATTCTGGCTCGATGA
GCAGGCAGCCGAAACCCTCTTCCTTTCTAGCGTCACGATCGCCGAGCTGATGTTTGGAATCGGCGCCCTCCCGGCTGGCA
AACGCAAGGAAAGGCTCTCCGACGCGTTGGACGGTCTGATGGAACTCTTCGAACGCCGTATTTTGGCTTTCGACATTACA
GCGGCACGGCGCTATGCCGATCTCGCGGTCAAGGCCCGAACTGCTGGCAGAGGATTTCCCACTCCGGACGGCTATATCGC
CGCTATCGCGGCATCGAAAGGGTTCGCCGTAGCCACGCGCGATACAAGTGCTTTCGACGCTGCAGGCGTTGAAGTGATCA
ACCCCTGGGCGGCTTCGACCGCATAA
GTGATTATCCTTGATACGAACGTCGTTTCCGAGGCGATGAAACCCGCGCCCGACGAAACCGTGAAATTCTGGCTCGATGA
GCAGGCAGCCGAAACCCTCTTCCTTTCTAGCGTCACGATCGCCGAGCTGATGTTTGGAATCGGCGCCCTCCCGGCTGGCA
AACGCAAGGAAAGGCTCTCCGACGCGTTGGACGGTCTGATGGAACTCTTCGAACGCCGTATTTTGGCTTTCGACATTACA
GCGGCACGGCGCTATGCCGATCTCGCGGTCAAGGCCCGAACTGCTGGCAGAGGATTTCCCACTCCGGACGGCTATATCGC
CGCTATCGCGGCATCGAAAGGGTTCGCCGTAGCCACGCGCGATACAAGTGCTTTCGACGCTGCAGGCGTTGAAGTGATCA
ACCCCTGGGCGGCTTCGACCGCATAA
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT209351 WP_004177809.1 NZ_CP079150:c5052549-5051791 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT209351 NZ_CP104041:57619-57873 [Rhizobium leguminosarum bv. viciae]
ATGCCCGCAGTCACAATCAGAAACCTCTCCGAGGCGACCCACCGTGCTCTCAAGGTGCGTGCGGCTCATCACGGGCGCAG
CACCGAAGCGGAAATGCGCGAAATCCTCGAGGCTGCCGTCCGTCCGGAAACGCGGCTGCATCTTGGCAGCGCGCTCGCCG
AACGGAGTCGTCGCCTCGGGTTGACAAATGAGGACCTTGCCGTTCTGGACCAAGCTCGCGACGCATTGCCTGCAAAGCCG
TTGAGCTTTGAGTGA
ATGCCCGCAGTCACAATCAGAAACCTCTCCGAGGCGACCCACCGTGCTCTCAAGGTGCGTGCGGCTCATCACGGGCGCAG
CACCGAAGCGGAAATGCGCGAAATCCTCGAGGCTGCCGTCCGTCCGGAAACGCGGCTGCATCTTGGCAGCGCGCTCGCCG
AACGGAGTCGTCGCCTCGGGTTGACAAATGAGGACCTTGCCGTTCTGGACCAAGCTCGCGACGCATTGCCTGCAAAGCCG
TTGAGCTTTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|