Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4895173..4895689 Replicon chromosome
Accession NZ_CP079150
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC07_CMC432PC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KWY72_RS23680 Protein ID WP_004178374.1
Coordinates 4895173..4895457 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KWY72_RS23685 Protein ID WP_002886901.1
Coordinates 4895447..4895689 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY72_RS23655 (4890657) 4890657..4890920 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KWY72_RS23660 (4891050) 4891050..4891223 + 174 WP_032408826.1 hypothetical protein -
KWY72_RS23665 (4891226) 4891226..4891969 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWY72_RS23670 (4892326) 4892326..4894464 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWY72_RS23675 (4894705) 4894705..4895169 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWY72_RS23680 (4895173) 4895173..4895457 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY72_RS23685 (4895447) 4895447..4895689 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWY72_RS23690 (4895767) 4895767..4897677 - 1911 WP_004178373.1 PRD domain-containing protein -
KWY72_RS23695 (4897700) 4897700..4898854 - 1155 WP_004178372.1 lactonase family protein -
KWY72_RS23700 (4898921) 4898921..4899661 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209350 WP_004178374.1 NZ_CP079150:c4895457-4895173 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209350 NZ_CP104040:c763641-762379 [Rhizobium leguminosarum bv. viciae]
ATGACATCAAGGCTTCTCAACGTCTGGTGGGGCGGCCGCATTGTCGGTCAATTCACGCAGGACAGACACGGCGATATCGG
CTTTGTCTATGCGCGAGCCTGGCTGGACGATGACAAAACGCTGCCGCTCTCGGCGTCTCTGCCGAAACGACTGGAGCGAT
TTACCCGCCAGGAATGCCGACCGTTTTTCGGCGGCCTGCTGCCCGAGGAAAGCCAGCGCCTGGCCGCAGCACGGGCCTTG
GGCGTGTCTCCCGACAATGACTTTGCGCTTCTCGATCACCTGGGCGGCGATGTCGCCGGTGCGCTGCAACTGCTTGCCGA
AGGTGAGGCACCGACCGAGACTGGGTCGATTGCAGATCGCCAGCCCGTGCCCCTGGACGAAGCAGGCATCGTTGCCGTGC
TGGAGGCGCTACCCGTGCGGCCTCTGCTGGCCGGTGAGGAAGGCCTCAGACTGTCGCTTGCCGGCGCGCAGTCCAAACTG
CCGGTTATTCTGGTCGATGGCCGGATCGAGCTTCCCCTGCCCGGTCAGGCCACAACCCATATTCTGAAGCCGCCGATAGC
CGGCTTCAAGGCGACGACCGAGAACGAAGCTTTCGTGATGAGGCTTGCGGCCGCCAGCGGGCTCGATGTCGCAGCCGCCG
AACCGAGATATGTGCAGGGACGCCCGTTCCTTCTGGTCGAACGATATGACCGCGTGCGCGGCGCCGGCGGACTGGTTCAT
CGCATCCACCAGGAAGATTTCTGCCAGGCACTCAGCGTGCCGCCGGAAACGAAATATGCGAGCGAAGGCGGGCCGACCTT
CAAGGATGGCTTCGATCTCATACGGCGGATTTCGGCAAGGCCGGCTGTCGACGTGCTGAAGCTGCTGGACGCGGCCATCT
TCAACCTGATCGCCGGAAATGCCGATGCCCACGGCAAGAACTTCTCCATCCTCTACGATAGCCAAGGCCCGCGGCTGGCA
AAACTCTATGACCTCCTCTCCACCGTGATCTATCCGGACCTGTCGCCAAGGCTGGCGATGAGAATCGGCCAGCGCGCCAC
ACTGGCCGAAATGGATGCCGAGGGCTGGAAGGCCTTTGCGGAAGAAGCCGGCATCGGCACTCCGCTGTTGCGCCGCCGCG
TGAACGAGCTTTGCGACAAGGTGCTGACATTGACCGGCAAGGTCGCCGATGAGCTGGCAGAGGTATCGCCCGATCGAGGA
TCGATCGACGCGATCGCCGGCGTGATAACAGACCGAGCCGAGACAGCGAGGTTGACTTTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209350 WP_002886901.1 NZ_CP079150:c4895689-4895447 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209350 NZ_CP104040:c763868-763638 [Rhizobium leguminosarum bv. viciae]
ATGCCAAAACACGTACAGAGTCCAGCCGACATCGGCGCCCTGGTTCGAAGCACCCGCAAGGAGCAAAACCTGCGGCAGGA
CGAGCTTGCCGGCGTTGCCGGTGTCGGGCTTCGCTTTATCGTCGACCTCGAAGCCGGCAAGCCCACGGCGCAGATCGGCA
AAGTCCTGCAGGTTCTGCAAACGCTTGGCTGCTCCCTCGACATTCTGGCTCCCGGCGAGCGCAGGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References