Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2816455..2818043 | Replicon | chromosome |
| Accession | NZ_CP079150 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC07_CMC432PC | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | KWY72_RS13830 | Protein ID | WP_004179815.1 |
| Coordinates | 2816455..2817777 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | KWY72_RS13835 | Protein ID | WP_004176198.1 |
| Coordinates | 2817777..2818043 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY72_RS13815 (2811511) | 2811511..2814012 | + | 2502 | WP_004179823.1 | fimbria/pilus outer membrane usher protein | - |
| KWY72_RS13820 (2814000) | 2814000..2815004 | + | 1005 | WP_004179822.1 | fimbrial protein | - |
| KWY72_RS13825 (2815146) | 2815146..2816438 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| KWY72_RS13830 (2816455) | 2816455..2817777 | - | 1323 | WP_004179815.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| KWY72_RS13835 (2817777) | 2817777..2818043 | - | 267 | WP_004176198.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| KWY72_RS13840 (2818309) | 2818309..2818635 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| KWY72_RS13845 (2818632) | 2818632..2819132 | - | 501 | WP_004179811.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| KWY72_RS13850 (2819110) | 2819110..2820489 | - | 1380 | WP_004179808.1 | nucleobase:cation symporter-2 family protein | - |
| KWY72_RS13855 (2820835) | 2820835..2821989 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| KWY72_RS13860 (2821970) | 2821970..2822893 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49152.42 Da Isoelectric Point: 7.2850
>T209346 WP_004179815.1 NZ_CP079150:c2817777-2816455 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T209346 NZ_CP104036:287635-288162 [Rhizobium leguminosarum bv. viciae]
GTGACCCTCCCCGTCTGGCATGAAGAGCCGATCGCTAAGTCGCACGATCGGGCCGCATTCGATTGTGGTGATGCGGCAAT
GAACGAGTTCATTCGGCGCTTAGCTCGGCAGAGCCATGAGCAGAATGCGGCGAAGACCTTCTGCGCTATCGACAAGGCCC
AACCTGATTGCATCCTCGGATTCTACACAGTCGCGCCTTCGGCCGTTACGCATGAGGCCGTGCCTCCGAAGATGACGAGA
GGCCTCGCGCGCCATGAAGTCGCAGGCTTCAAGCTCGCGCGCTTGGCAACCGACATAAAGGTGGCGGGAAAAGGTTTAGG
CGGCCAGTTCATCGCCGCTGCGGCGCTCCGTTGCCTGCGGCTCGCCAGCGAGGGCGGCGGGATCCTGCTTATCATCGATA
CCAAGAACGAACGCGCCGCCCATTGGTATGCCGGCTACGGCGCCGAACCGCTGCAAGGGAAACCGCTCACCCTCGTTATG
CCGCTTGCCACCTTCGCCGCCGACTTCAAGGCCAAGGGGCTTTTGTAG
GTGACCCTCCCCGTCTGGCATGAAGAGCCGATCGCTAAGTCGCACGATCGGGCCGCATTCGATTGTGGTGATGCGGCAAT
GAACGAGTTCATTCGGCGCTTAGCTCGGCAGAGCCATGAGCAGAATGCGGCGAAGACCTTCTGCGCTATCGACAAGGCCC
AACCTGATTGCATCCTCGGATTCTACACAGTCGCGCCTTCGGCCGTTACGCATGAGGCCGTGCCTCCGAAGATGACGAGA
GGCCTCGCGCGCCATGAAGTCGCAGGCTTCAAGCTCGCGCGCTTGGCAACCGACATAAAGGTGGCGGGAAAAGGTTTAGG
CGGCCAGTTCATCGCCGCTGCGGCGCTCCGTTGCCTGCGGCTCGCCAGCGAGGGCGGCGGGATCCTGCTTATCATCGATA
CCAAGAACGAACGCGCCGCCCATTGGTATGCCGGCTACGGCGCCGAACCGCTGCAAGGGAAACCGCTCACCCTCGTTATG
CCGCTTGCCACCTTCGCCGCCGACTTCAAGGCCAAGGGGCTTTTGTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.36 Da Isoelectric Point: 8.5912
>AT209346 WP_004176198.1 NZ_CP079150:c2818043-2817777 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT209346 NZ_CP104036:287360-287638 [Rhizobium leguminosarum bv. viciae]
ATGCCGAGAACCGCGGACAGTAAAACCGAACGCTACCAGCTGCGCATCCCGCCAAAGCAGAAGGCAATGATCGCGCGCGC
GGCTGCCCTCTCGAACAAGGATATGGCCGATTTCATTCTCGATAAGATCGTACCTGAAGCCGAAGCCGTCATCCAGGCTG
CGGAAGTTGAGACCGTTTCGAGCCGCGATTTCATCCGCATCCTCGATCTGCTTGAACACCCGCCCAAACCGAACGCGAAA
CTACGAGCCGCGATCTCTGCTCTACCGGATGCCTTGTGA
ATGCCGAGAACCGCGGACAGTAAAACCGAACGCTACCAGCTGCGCATCCCGCCAAAGCAGAAGGCAATGATCGCGCGCGC
GGCTGCCCTCTCGAACAAGGATATGGCCGATTTCATTCTCGATAAGATCGTACCTGAAGCCGAAGCCGTCATCCAGGCTG
CGGAAGTTGAGACCGTTTCGAGCCGCGATTTCATCCGCATCCTCGATCTGCTTGAACACCCGCCCAAACCGAACGCGAAA
CTACGAGCCGCGATCTCTGCTCTACCGGATGCCTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|