Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 818521..819178 Replicon chromosome
Accession NZ_CP079150
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC07_CMC432PC

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag KWY72_RS04020 Protein ID WP_004181233.1
Coordinates 818768..819178 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KWY72_RS04015 Protein ID WP_002916312.1
Coordinates 818521..818787 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY72_RS03990 (813677) 813677..815110 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
KWY72_RS03995 (815229) 815229..815957 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KWY72_RS04000 (816007) 816007..816318 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KWY72_RS04005 (816482) 816482..817141 + 660 WP_002916317.1 hemolysin III family protein -
KWY72_RS04010 (817292) 817292..818275 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
KWY72_RS04015 (818521) 818521..818787 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KWY72_RS04020 (818768) 818768..819178 + 411 WP_004181233.1 protein YgfX Toxin
KWY72_RS04025 (819185) 819185..819706 - 522 WP_004144730.1 flavodoxin FldB -
KWY72_RS04030 (819807) 819807..820703 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KWY72_RS04035 (820726) 820726..821439 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KWY72_RS04040 (821445) 821445..823178 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T209337 WP_004181233.1 NZ_CP079150:818768-819178 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T209337 NZ_CP104032:c86442-86293 [Klebsiella pneumoniae]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT209337 WP_002916312.1 NZ_CP079150:818521-818787 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT209337 NZ_CP104032:86486-86547 [Klebsiella pneumoniae]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References