Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4190019..4190638 Replicon chromosome
Accession NZ_CP079145
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC06_CMC387MC

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KWY71_RS20415 Protein ID WP_002892050.1
Coordinates 4190420..4190638 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KWY71_RS20410 Protein ID WP_002892066.1
Coordinates 4190019..4190393 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY71_RS20400 (4185171) 4185171..4186364 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KWY71_RS20405 (4186387) 4186387..4189533 + 3147 WP_218410910.1 multidrug efflux RND transporter permease subunit AcrB -
KWY71_RS20410 (4190019) 4190019..4190393 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KWY71_RS20415 (4190420) 4190420..4190638 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KWY71_RS20420 (4190797) 4190797..4191363 + 567 WP_002892030.1 maltose O-acetyltransferase -
KWY71_RS20425 (4191335) 4191335..4191475 - 141 WP_004147370.1 hypothetical protein -
KWY71_RS20430 (4191496) 4191496..4191966 + 471 WP_002892026.1 YlaC family protein -
KWY71_RS20435 (4191941) 4191941..4193392 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
KWY71_RS20440 (4193493) 4193493..4194191 + 699 WP_004178762.1 GNAT family protein -
KWY71_RS20445 (4194188) 4194188..4194328 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KWY71_RS20450 (4194328) 4194328..4194591 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209327 WP_002892050.1 NZ_CP079145:4190420-4190638 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209327 NZ_CP104030:877987-878394 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCGTGC
GCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCCGAA
TGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGGACA
GCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGGCGC
AGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT209327 WP_002892066.1 NZ_CP079145:4190019-4190393 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209327 NZ_CP104030:877740-878006 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References