20931

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 240105..240747 Replicon chromosome
Accession NC_004722
Organism Bacillus cereus ATCC 14579

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag BC_RS01360 Protein ID WP_000635963.1
Coordinates 240397..240747 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BC_RS01355 Protein ID WP_000004570.1
Coordinates 240105..240392 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BC_RS01330 (BC0260) 235422..236384 + 963 WP_000961166.1 UV DNA damage repair endonuclease UvsE -
BC_RS01335 (BC0261) 236377..236949 - 573 WP_000908523.1 rhomboid family intramembrane serine protease -
BC_RS01340 (BC0262) 237043..237402 + 360 WP_000583416.1 holo-ACP synthase -
BC_RS01345 (BC0263) 237559..238509 + 951 WP_164928341.1 outer membrane lipoprotein carrier protein LolA -
BC_RS01350 (BC0264) 238627..239796 + 1170 WP_000390615.1 alanine racemase -
BC_RS01355 (BC0265) 240105..240392 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
BC_RS01360 (BC0266) 240397..240747 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BC_RS01365 (BC0267) 240815..242983 + 2169 WP_000426247.1 helix-hairpin-helix domain-containing protein -
BC_RS01370 243041..243157 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
BC_RS01375 (BC0268) 243353..243811 + 459 WP_000344231.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T20931 WP_000635963.1 NC_004722:240397-240747 [Bacillus cereus ATCC 14579]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T20931 NC_004722:240397-240747 [Bacillus cereus ATCC 14579]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT20931 WP_000004570.1 NC_004722:240105-240392 [Bacillus cereus ATCC 14579]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT20931 NC_004722:240105-240392 [Bacillus cereus ATCC 14579]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References