Detailed information of TA system TA209302

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4048732..4049389
• Replicon: chromosome
• Accession: NZ_CP079138
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC05_CMC387PC

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KWY70_RS19510
• Protein ID: WP_004181233.1
• Coordinates: 4048979..4049389 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KWY70_RS19505
• Protein ID: WP_002916312.1
• Coordinates: 4048732..4048998 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY70_RS19480 (4043888)	4043888..4045321	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
KWY70_RS19485 (4045440)	4045440..4046168	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KWY70_RS19490 (4046218)	4046218..4046529	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KWY70_RS19495 (4046693)	4046693..4047352	+	660	WP_002916317.1	hemolysin III family protein	-
KWY70_RS19500 (4047503)	4047503..4048486	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
KWY70_RS19505 (4048732)	4048732..4048998	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KWY70_RS19510 (4048979)	4048979..4049389	+	411	WP_004181233.1	protein YgfX	Toxin
KWY70_RS19515 (4049396)	4049396..4049917	-	522	WP_004144730.1	flavodoxin FldB	-
KWY70_RS19520 (4050018)	4050018..4050914	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KWY70_RS19525 (4050937)	4050937..4051650	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KWY70_RS19530 (4051656)	4051656..4053389	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T209302 WP_004181233.1 NZ_CP079138:4048979-4049389 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T209302 NZ_CP104020:122119-122271 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT209302 WP_002916312.1 NZ_CP079138:4048732-4048998 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209302 NZ_CP104020:121495-122094 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41