Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 2824451..2826132 | Replicon | chromosome |
| Accession | NZ_CP079138 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC05_CMC387PC | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | - |
| Locus tag | KWY70_RS13610 | Protein ID | WP_004178299.1 |
| Coordinates | 2824451..2825368 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | KWY70_RS13615 | Protein ID | WP_004177809.1 |
| Coordinates | 2825374..2826132 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY70_RS13590 (2819757) | 2819757..2821277 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| KWY70_RS13595 (2821274) | 2821274..2822272 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| KWY70_RS13600 (2822303) | 2822303..2823244 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| KWY70_RS13605 (2823319) | 2823319..2824326 | + | 1008 | WP_004178300.1 | carbohydrate kinase family protein | - |
| KWY70_RS13610 (2824451) | 2824451..2825368 | - | 918 | WP_004178299.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| KWY70_RS13615 (2825374) | 2825374..2826132 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| KWY70_RS13620 (2826218) | 2826218..2826946 | - | 729 | WP_004178298.1 | response regulator transcription factor | - |
| KWY70_RS13625 (2827219) | 2827219..2829366 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| KWY70_RS13630 (2829596) | 2829596..2830282 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34649.06 Da Isoelectric Point: 5.4707
>T209299 WP_004178299.1 NZ_CP079138:c2825368-2824451 [Klebsiella pneumoniae subsp. pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
>T209299 NZ_CP104014:c3839136-3838726 [Enterobacter sp. CP102]
GTGGTCCTGTGGCAATCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTATTACTGATGCCGTGGCCGCTTAGCTATACCCCTCTCTGGCTGCTGTTACTGTCATTCGTGGTGTTTGACAGCG
TGCGTAGTCAGCGCCGTATCAATGCCCGTCAGGGCGAAATCAAACTAATGATGGATTCACGCCTGCGCTGGCAGGGGAAA
GAGTGGGAAATTATAGGCACGCCATGGATGCTCAGTTCCGGCATGATGCTCCGGCTGCGTAAGGTGGGCGGCGGACGTCG
CCAGCACTTGTGGCTGGCAGCGGACAGTATGGATGAAGTGGAGTGGCGGGATCTGCGTCGGATGGTATTGCAACAACCGA
CGCAGGAATAG
GTGGTCCTGTGGCAATCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTCGCGGC
ATTTGTATTACTGATGCCGTGGCCGCTTAGCTATACCCCTCTCTGGCTGCTGTTACTGTCATTCGTGGTGTTTGACAGCG
TGCGTAGTCAGCGCCGTATCAATGCCCGTCAGGGCGAAATCAAACTAATGATGGATTCACGCCTGCGCTGGCAGGGGAAA
GAGTGGGAAATTATAGGCACGCCATGGATGCTCAGTTCCGGCATGATGCTCCGGCTGCGTAAGGTGGGCGGCGGACGTCG
CCAGCACTTGTGGCTGGCAGCGGACAGTATGGATGAAGTGGAGTGGCGGGATCTGCGTCGGATGGTATTGCAACAACCGA
CGCAGGAATAG
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT209299 WP_004177809.1 NZ_CP079138:c2826132-2825374 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
>AT209299 NZ_CP104014:c3839383-3839117 [Enterobacter sp. CP102]
ATGGATATTAACAACAAGGCCCGTATCCACTGGGCTTGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATACGAGTACGACAGCTTAAGCGAAGACGATAAGCGTCTGTTCGTTCGCCTGCTTGAATCCGACGATCCTGATT
TGTTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAGGCCCGTATCCACTGGGCTTGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATACGAGTACGACAGCTTAAGCGAAGACGATAAGCGTCTGTTCGTTCGCCTGCTTGAATCCGACGATCCTGATT
TGTTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|