Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2668756..2669272 Replicon chromosome
Accession NZ_CP079138
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC05_CMC387PC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KWY70_RS12815 Protein ID WP_004178374.1
Coordinates 2668756..2669040 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KWY70_RS12820 Protein ID WP_002886901.1
Coordinates 2669030..2669272 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY70_RS12790 (2664240) 2664240..2664503 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KWY70_RS12795 (2664633) 2664633..2664806 + 174 WP_032408826.1 hypothetical protein -
KWY70_RS12800 (2664809) 2664809..2665552 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWY70_RS12805 (2665909) 2665909..2668047 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWY70_RS12810 (2668288) 2668288..2668752 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWY70_RS12815 (2668756) 2668756..2669040 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY70_RS12820 (2669030) 2669030..2669272 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWY70_RS12825 (2669350) 2669350..2671260 - 1911 WP_004178373.1 PRD domain-containing protein -
KWY70_RS12830 (2671283) 2671283..2672437 - 1155 WP_004178372.1 lactonase family protein -
KWY70_RS12835 (2672504) 2672504..2673244 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209298 WP_004178374.1 NZ_CP079138:c2669040-2668756 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209298 NZ_CP104014:c2800033-2799929 [Enterobacter sp. CP102]
GGCAAGGCGATTTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATA
CAGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209298 WP_002886901.1 NZ_CP079138:c2669272-2669030 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209298 NZ_CP104014:2799924-2800068 [Enterobacter sp. CP102]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAAATCGCCTTGCCTTTTAAGAATAGATGAGAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References