Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 590038..591626 Replicon chromosome
Accession NZ_CP079138
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC05_CMC387PC

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KWY70_RS02965 Protein ID WP_004179815.1
Coordinates 590038..591360 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag KWY70_RS02970 Protein ID WP_004176198.1
Coordinates 591360..591626 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY70_RS02950 (585094) 585094..587595 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
KWY70_RS02955 (587583) 587583..588587 + 1005 WP_004179822.1 fimbrial protein -
KWY70_RS02960 (588729) 588729..590021 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
KWY70_RS02965 (590038) 590038..591360 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
KWY70_RS02970 (591360) 591360..591626 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
KWY70_RS02975 (591892) 591892..592218 - 327 WP_002904788.1 hydroxyisourate hydrolase -
KWY70_RS02980 (592215) 592215..592715 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
KWY70_RS02985 (592693) 592693..594072 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
KWY70_RS02990 (594418) 594418..595572 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
KWY70_RS02995 (595553) 595553..596476 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T209294 WP_004179815.1 NZ_CP079138:c591360-590038 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T209294 NZ_CP104014:573109-573258 [Enterobacter sp. CP102]
ATGCCTACGGAGTTTGAATGGAATAGCAGCAAGGCGAAAAGCAACCTGCAAAAGCACGGGATCCGTTTTGAAAGCGGCAA
TGAAATCATTCGTATCATCAGCGCACGTAAGGCAGACCGTAAAGAAAGGAGCCGTTATGAGCATTGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT209294 WP_004176198.1 NZ_CP079138:c591626-591360 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT209294 NZ_CP104014:573245-573547 [Enterobacter sp. CP102]
ATGAGCATTGTTAAACATAAACGCGGGAGTGCTGCTGAAGTTAGCGTTCATCGCGAGGCCGAACTTCACGCGTTAGCGGA
AAAACCCGACGCAGAAATTGACTATAGCGATATTCCGGCAATGGATGAGGCGCTGTGGAACGACGCGGTACGCGGCAAGT
TCTATCGTCCCTTAAAAACCCAGGCGTCTGTGCGTATCGATGCAGATGTTATGGAATGGCTTAAACGCCCGGGAAAAGGG
TATCAGACGCGACTCAACGCTATTTTACGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References