Detailed information of TA system TA209294

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 590038..591626
• Replicon: chromosome
• Accession: NZ_CP079138
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC05_CMC387PC

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KWY70_RS02965
• Protein ID: WP_004179815.1
• Coordinates: 590038..591360 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KWY70_RS02970
• Protein ID: WP_004176198.1
• Coordinates: 591360..591626 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWY70_RS02950 (585094)	585094..587595	+	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-
KWY70_RS02955 (587583)	587583..588587	+	1005	WP_004179822.1	fimbrial protein	-
KWY70_RS02960 (588729)	588729..590021	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KWY70_RS02965 (590038)	590038..591360	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KWY70_RS02970 (591360)	591360..591626	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KWY70_RS02975 (591892)	591892..592218	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
KWY70_RS02980 (592215)	592215..592715	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KWY70_RS02985 (592693)	592693..594072	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KWY70_RS02990 (594418)	594418..595572	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KWY70_RS02995 (595553)	595553..596476	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209294 WP_004179815.1 NZ_CP079138:c591360-590038 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209294 NZ_CP104014:573109-573258 [Enterobacter sp. CP102]
ATGCCTACGGAGTTTGAATGGAATAGCAGCAAGGCGAAAAGCAACCTGCAAAAGCACGGGATCCGTTTTGAAAGCGGCAA
TGAAATCATTCGTATCATCAGCGCACGTAAGGCAGACCGTAAAGAAAGGAGCCGTTATGAGCATTGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209294 WP_004176198.1 NZ_CP079138:c591626-591360 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209294 NZ_CP104014:573245-573547 [Enterobacter sp. CP102]
ATGAGCATTGTTAAACATAAACGCGGGAGTGCTGCTGAAGTTAGCGTTCATCGCGAGGCCGAACTTCACGCGTTAGCGGA
AAAACCCGACGCAGAAATTGACTATAGCGATATTCCGGCAATGGATGAGGCGCTGTGGAACGACGCGGTACGCGGCAAGT
TCTATCGTCCCTTAAAAACCCAGGCGTCTGTGCGTATCGATGCAGATGTTATGGAATGGCTTAAACGCCCGGGAAAAGGG
TATCAGACGCGACTCAACGCTATTTTACGCGAGGCGATGCTGCGCGATCAGAACAAAAAATAG