Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 66624..67267 | Replicon | plasmid pAI1235M_P3 |
| Accession | NZ_CP079134 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC04_AI1235MC | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | D8L2J9 |
| Locus tag | KWY69_RS27980 | Protein ID | WP_001044770.1 |
| Coordinates | 66624..67040 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | KWY69_RS27985 | Protein ID | WP_001261282.1 |
| Coordinates | 67037..67267 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY69_RS27950 (KWY69_27950) | 61792..62580 | + | 789 | WP_001206315.1 | ANT(3'')-Ia family aminoglycoside nucleotidyltransferase AadA1 | - |
| KWY69_RS27955 (KWY69_27955) | 62640..63464 | + | 825 | WP_000722315.1 | oxacillin-hydrolyzing class D beta-lactamase OXA-9 | - |
| KWY69_RS27960 (KWY69_27960) | 63664..63981 | + | 318 | Protein_66 | recombinase family protein | - |
| KWY69_RS27965 (KWY69_27965) | 64164..65024 | + | 861 | WP_000027057.1 | broad-spectrum class A beta-lactamase TEM-1 | - |
| KWY69_RS27975 (KWY69_27975) | 65861..66550 | - | 690 | Protein_69 | AAA family ATPase | - |
| KWY69_RS27980 (KWY69_27980) | 66624..67040 | - | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| KWY69_RS27985 (KWY69_27985) | 67037..67267 | - | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| KWY69_RS27990 (KWY69_27990) | 67224..67685 | + | 462 | WP_072202616.1 | hypothetical protein | - |
| KWY69_RS27995 (KWY69_27995) | 67829..68179 | + | 351 | WP_000493378.1 | hypothetical protein | - |
| KWY69_RS28000 (KWY69_28000) | 68230..68973 | + | 744 | WP_000129823.1 | hypothetical protein | - |
| KWY69_RS28005 (KWY69_28005) | 68970..69746 | + | 777 | WP_000015958.1 | site-specific integrase | - |
| KWY69_RS28010 (KWY69_28010) | 69804..70061 | - | 258 | WP_000764642.1 | hypothetical protein | - |
| KWY69_RS28015 (KWY69_28015) | 70190..70294 | - | 105 | WP_032409716.1 | hypothetical protein | - |
| KWY69_RS28020 (KWY69_28020) | 70829..71611 | + | 783 | Protein_78 | replication initiation protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | qnrB1 / aac(3)-IId / blaCTX-M-15 / aac(6')-Ib / ant(3'')-Ia / blaOXA-9 / blaTEM-1A / ARR-3 / ere(A) / cmlA1 / qacE / sul1 / aph(6)-Id / aph(3'')-Ib / sul2 | - | 1..96887 | 96887 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T209291 WP_001044770.1 NZ_CP079134:c67040-66624 [Klebsiella pneumoniae subsp. pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
>T209291 NZ_CP104011:3153141-3153488 [Pseudomonas sp. GCEP-101]
GTGTCCAGGTTGGTCGTCCGATTTACCCACACCGCAGAACAGAGCATCCAGGACCAGGTTCATCACCTGGTTCCGTTCCT
GGGGCAGCAGAATGCCCTGGATTCGCTCCTTGAACTGATCGTCGAGATCGAAGAGAAGCTGCCGCGAGCGCCGGCAGGAT
ATCCTGTCAGCGAGCAAGCGAGCCTGCTGGGCGTATTGCACTTCCGCGAGTTCAACACGGGGCCGTACCGCGTGTTCTAT
GAGGTGCATGAACACCTGAGCGAAATCGCCGTCATTCTGGTGCTGCGGCAGAAGCAGAGTGTGCAGCAGCAACTGATTCG
TTACTGCCTTGTCGGGCCTTTTGAATAG
GTGTCCAGGTTGGTCGTCCGATTTACCCACACCGCAGAACAGAGCATCCAGGACCAGGTTCATCACCTGGTTCCGTTCCT
GGGGCAGCAGAATGCCCTGGATTCGCTCCTTGAACTGATCGTCGAGATCGAAGAGAAGCTGCCGCGAGCGCCGGCAGGAT
ATCCTGTCAGCGAGCAAGCGAGCCTGCTGGGCGTATTGCACTTCCGCGAGTTCAACACGGGGCCGTACCGCGTGTTCTAT
GAGGTGCATGAACACCTGAGCGAAATCGCCGTCATTCTGGTGCTGCGGCAGAAGCAGAGTGTGCAGCAGCAACTGATTCG
TTACTGCCTTGTCGGGCCTTTTGAATAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT209291 WP_001261282.1 NZ_CP079134:c67267-67037 [Klebsiella pneumoniae subsp. pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT209291 NZ_CP104011:3152880-3153131 [Pseudomonas sp. GCEP-101]
ATGCGCGTCGAGACTATCAGTTACCTGAAGCGTCACGCTGCCGACCTGGATCTGACCGAGCCCATGGTTGTCACCCAGAA
TGGCGTGCCAGCCTATGTTGTCGAGTCCTACGCCGAGCGTCAGCAGCGCGACGAGGCGATTGCCCTGGTCAAGCTGTTGG
CCATGGGCTCTCGGCAATATGCAGAGGGCAAACACAGTTCAGCTGACGACCTCAAGGCCCGGCTTGCCAAAAGATTCTCG
CCGTCTGATTGA
ATGCGCGTCGAGACTATCAGTTACCTGAAGCGTCACGCTGCCGACCTGGATCTGACCGAGCCCATGGTTGTCACCCAGAA
TGGCGTGCCAGCCTATGTTGTCGAGTCCTACGCCGAGCGTCAGCAGCGCGACGAGGCGATTGCCCTGGTCAAGCTGTTGG
CCATGGGCTCTCGGCAATATGCAGAGGGCAAACACAGTTCAGCTGACGACCTCAAGGCCCGGCTTGCCAAAAGATTCTCG
CCGTCTGATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GYM2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZG3 |