Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 58669..59405 | Replicon | plasmid pAI1235M_P1 |
| Accession | NZ_CP079132 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain WRC04_AI1235MC | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | L7SZ15 |
| Locus tag | KWY69_RS26360 | Protein ID | WP_003026803.1 |
| Coordinates | 58923..59405 (+) | Length | 161 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | L7SZ29 |
| Locus tag | KWY69_RS26355 | Protein ID | WP_003026799.1 |
| Coordinates | 58669..58935 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWY69_RS26310 (KWY69_26310) | 54731..55093 | - | 363 | WP_004152100.1 | arsenite efflux transporter metallochaperone ArsD | - |
| KWY69_RS26315 (KWY69_26315) | 55143..55493 | - | 351 | WP_004152101.1 | As(III)-sensing metalloregulatory transcriptional repressor ArsR | - |
| KWY69_RS26320 (KWY69_26320) | 55851..56120 | + | 270 | WP_004152102.1 | hypothetical protein | - |
| KWY69_RS26325 (KWY69_26325) | 56108..56683 | + | 576 | WP_004152103.1 | hypothetical protein | - |
| KWY69_RS26330 (KWY69_26330) | 56714..57208 | + | 495 | WP_004152104.1 | DNA-binding protein | - |
| KWY69_RS26335 (KWY69_26335) | 57252..57620 | + | 369 | WP_004152105.1 | hypothetical protein | - |
| KWY69_RS26340 (KWY69_26340) | 57654..57857 | + | 204 | WP_004152106.1 | HHA domain-containing protein | - |
| KWY69_RS26345 (KWY69_26345) | 57906..58163 | + | 258 | WP_004152107.1 | hypothetical protein | - |
| KWY69_RS26350 (KWY69_26350) | 58239..58493 | + | 255 | WP_004152108.1 | hypothetical protein | - |
| KWY69_RS26355 (KWY69_26355) | 58669..58935 | + | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
| KWY69_RS26360 (KWY69_26360) | 58923..59405 | + | 483 | WP_003026803.1 | GNAT family N-acetyltransferase | Toxin |
| KWY69_RS26365 (KWY69_26365) | 59606..61009 | + | 1404 | WP_001567368.1 | ISNCY-like element ISKpn21 family transposase | - |
| KWY69_RS26370 (KWY69_26370) | 61038..61670 | - | 633 | WP_001567369.1 | hypothetical protein | - |
| KWY69_RS26375 (KWY69_26375) | 61900..63246 | + | 1347 | WP_020314316.1 | ISNCY family transposase | - |
| KWY69_RS29100 | 63407..63538 | + | 132 | WP_004218042.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | catA1 | - | 1..198536 | 198536 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 161 a.a. Molecular weight: 17353.97 Da Isoelectric Point: 9.5822
>T209290 WP_003026803.1 NZ_CP079132:58923-59405 [Klebsiella pneumoniae subsp. pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP
Download Length: 483 bp
>T209290 NZ_CP104011:c3117311-3116898 [Pseudomonas sp. GCEP-101]
ATGCTCGATACCAACATCTGCTCGCTCATCATGCGCAAGAACCCACCGCAGGTTCTGCAGCGACTGCAGCACGCCGCGGA
AGCCGGCAATCGGCTGGTGATCTCAGCCATCACCTATGCGGAGCTGCGCTACGGCGCGGCATCGCCCAAAGCTCCCCGAG
CAGTGACGGCATGGATCGACGCGCTGGTTCAGCGTCTGGATGACGTGCTGCCCTGGGATAGCGACGCCGTGGATGCCTCC
GCGAAGCTGATGCGGCAACTGCTCGACGCGGGGACGCCGATCGGCCCGAACGACACGGGCATCGCCGGGCATGCCCTGGC
GACCCAATGCATCGTCGTGACCAACAACACCCGCGAGTTTCGCCGGGTACCGGGGCTGCTCGTCGAGGACTGGTGCAGCG
ATCAGCCGACCTGA
ATGCTCGATACCAACATCTGCTCGCTCATCATGCGCAAGAACCCACCGCAGGTTCTGCAGCGACTGCAGCACGCCGCGGA
AGCCGGCAATCGGCTGGTGATCTCAGCCATCACCTATGCGGAGCTGCGCTACGGCGCGGCATCGCCCAAAGCTCCCCGAG
CAGTGACGGCATGGATCGACGCGCTGGTTCAGCGTCTGGATGACGTGCTGCCCTGGGATAGCGACGCCGTGGATGCCTCC
GCGAAGCTGATGCGGCAACTGCTCGACGCGGGGACGCCGATCGGCCCGAACGACACGGGCATCGCCGGGCATGCCCTGGC
GACCCAATGCATCGTCGTGACCAACAACACCCGCGAGTTTCGCCGGGTACCGGGGCTGCTCGTCGAGGACTGGTGCAGCG
ATCAGCCGACCTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT209290 WP_003026799.1 NZ_CP079132:58669-58935 [Klebsiella pneumoniae subsp. pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT209290 NZ_CP104011:c3117584-3117336 [Pseudomonas sp. GCEP-101]
ATGCCGACCACCACCGTTTCCCTGTTCCGCAATGGCAAGAACCAGGCCGTCCGAATCCCCCGGGACATGGAGTTCAAGGG
CGTGACCGAGTTGGTGATGACCCGTGAAGGCGACACCCTGACGCTGCGTCCGGCCCGCCCCACCTGGAGCAGCCTGGCCG
ACCTTGAGCCCATCGATGCCGACATCCTGTCCGATCGGCCCACGATGATCGAACCCGGCCGGGTCGATTTCAGCGACGAC
GAGGAGTGA
ATGCCGACCACCACCGTTTCCCTGTTCCGCAATGGCAAGAACCAGGCCGTCCGAATCCCCCGGGACATGGAGTTCAAGGG
CGTGACCGAGTTGGTGATGACCCGTGAAGGCGACACCCTGACGCTGCGTCCGGCCCGCCCCACCTGGAGCAGCCTGGCCG
ACCTTGAGCCCATCGATGCCGACATCCTGTCCGATCGGCCCACGATGATCGAACCCGGCCGGGTCGATTTCAGCGACGAC
GAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0J2GNW6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1Q8YL66 |