Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 132305..132821 Replicon chromosome
Accession NZ_CP079131
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC04_AI1235MC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KWY69_RS00540 Protein ID WP_004178374.1
Coordinates 132305..132589 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KWY69_RS00545 Protein ID WP_002886901.1
Coordinates 132579..132821 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWY69_RS00515 (127789) 127789..128052 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
KWY69_RS00520 (128182) 128182..128355 + 174 WP_032408826.1 hypothetical protein -
KWY69_RS00525 (128358) 128358..129101 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWY69_RS00530 (129458) 129458..131596 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWY69_RS00535 (131837) 131837..132301 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWY69_RS00540 (132305) 132305..132589 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWY69_RS00545 (132579) 132579..132821 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWY69_RS00550 (132899) 132899..134809 - 1911 WP_004178373.1 PRD domain-containing protein -
KWY69_RS00555 (134832) 134832..135986 - 1155 WP_004178372.1 lactonase family protein -
KWY69_RS00560 (136053) 136053..136793 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209274 WP_004178374.1 NZ_CP079131:c132589-132305 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209274 NZ_CP104001:c2906764-2906661 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209274 WP_002886901.1 NZ_CP079131:c132821-132579 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209274 NZ_CP104001:2906654-2906799 [Enterobacter roggenkampii]
AACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References