Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 5277214..5278024 Replicon chromosome
Accession NZ_CP079120
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC03_AI1235PC

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag KWV87_RS25600 Protein ID WP_004178461.1
Coordinates 5277491..5278024 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag KWV87_RS25595 Protein ID WP_002887278.1
Coordinates 5277214..5277480 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWV87_RS25575 (5273086) 5273086..5273430 - 345 WP_004197273.1 cation efflux system protein CusF -
KWV87_RS25580 (5273448) 5273448..5274833 - 1386 WP_004178457.1 efflux transporter outer membrane subunit -
KWV87_RS25585 (5275005) 5275005..5275688 + 684 WP_002887273.1 copper response regulator transcription factor CusR -
KWV87_RS25590 (5275678) 5275678..5277111 + 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
KWV87_RS25595 (5277214) 5277214..5277480 + 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
KWV87_RS25600 (5277491) 5277491..5278024 + 534 WP_004178461.1 type II toxin-antitoxin system toxin KacT Toxin
KWV87_RS25605 (5278072) 5278072..5279193 - 1122 WP_002887282.1 cupin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T209267 WP_004178461.1 NZ_CP079120:5277491-5278024 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T209267 NZ_CP103999:9184-10482 [Ketogulonicigenium vulgare]
ATGGGACGTCGCCGGGCCTATCTGCCATTGGATGTCTATATGAACGCACGTCTTGTCGGGCAGTTTGCGCGGCAAAGCGG
GGGCGCGCATCTGTTTACCTATGCGCAAAGTTGGCTGGGCTGGCCGGGCCGGCTGCCGATCTCGCGGGCGCTGCCATTAC
AGGGCGCACGCCATCAAGGCGCGGCGGTGATTGCGGTTTTCGACAACCTGCTGCCCGATCATCCGCAGATCCGCGACCGT
CTGGCGGCGCGGGTCGGGGCGGGCGGTGCGGATGCGTTCAGCCTGCTGGCCGAGATCGGGCGCGATTGCGTCGGCGCGCT
GCAATTTCTGCCAGCGGGCGAGATGCCTGACGCGCAGGGGCTGCAGGCCGATCCGCTGAGCGCGGCGCAGATTGGCGCGC
TGCTATCGAACCTGAGCGCCGCGCCGCTGGGGCTGGACCGCACGCGGGACTTCCGCATTTCGGTCGCTGGGGCGCAGGAA
AAGACGGCGCTGCTGCGGCAGGACGATCAGTGGTTCGCGCCGCGCGGGGCGACCCCTACGACCCATATCCTGAAACCCGC
GATCGGGCTGCTGCCCAGTGGGGTCGATCTGCGCAACGCCCCCCAGAACGAGCATTTCTGTCTGCGCCTGCCGGCGGGTT
TCGGTCTGCGCGTGGCTGACACGCAGGTTGCAGATTTCAATGGCGTCAGCACGCTGGTTGTCACCCGGTTTGACCGGCTG
TGGACGGCGGATGGGCGGTTGATCCGCCTGCCGCAAGAGGATTGCTGTCAGGCCCTCGGCGTGCCGTCCAGCCTGAAATA
TCAAAGCGATGGCGGCCCGGGCATCCGCGAGATCAGCGCGCTGTTGCAGGCCAGCGATCAGCCGGTGCAGGACCGGCTGG
ATTTTTTCAAGGCGAATATCCTGTTCTGGCTGATGGGCGCGACCGATGGTCATGCCAAGAATTTCAGCCTGTCCATGGCC
CCCGGCGGGCGGTTCCGGCTGGCACCGCTGTATGATGTGATCAGCCTGCAACCGGCACTGGCGGCGGGGCAGATGCAGCC
CGGGGATATGCGCCTCGCGATGCGGATGGGGGCAAGCCGCTATTATCGCATAGGGGATATCACCGGCCGCCATATTCTGG
AAAGCGGGCTGGATGCCGGATTGTCGCGGGTGCAGATCCTGGCGATTTGCGCTGAGATTGCCGAAAGCGCCGCCGCGGCC
TTTGAGGCGGCATCACACACAGTGCAGGACCAGGAGATGGTCGCGGCGATCCGCGCGGGGTTTGACCAACGCTTGCCAAG
ACTGATGACAATGACCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT209267 WP_002887278.1 NZ_CP079120:5277214-5277480 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT209267 NZ_CP103999:8933-9184 [Ketogulonicigenium vulgare]
ATGGACCATATCATTCGCTCACCCAAAGATATCGGACATGTGCTGCGGCAGGCCCGCAAGGCCGGGGGGCTGTCGCAGGC
TGACCTTGCCGCAAAAGCGGGCCTGTGGCAGCGCACGGTTTCCACGCTGGAAACCGGCGCGGCGGATGCAAGGCTGGAAA
CGCTGTTTGATCTGCTCGCCGCGCTGGATCTGGAATTGCAGGTCGTGCCGCGCAGCCGCACCGATCCCGACAGTTTTGCC
GATCTGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References