Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 5166437..5166953 Replicon chromosome
Accession NZ_CP079120
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC03_AI1235PC

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KWV87_RS25150 Protein ID WP_004178374.1
Coordinates 5166669..5166953 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KWV87_RS25145 Protein ID WP_002886901.1
Coordinates 5166437..5166679 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWV87_RS25130 (5162465) 5162465..5163205 + 741 WP_002886899.1 KDGP aldolase family protein -
KWV87_RS25135 (5163272) 5163272..5164426 + 1155 WP_004178372.1 lactonase family protein -
KWV87_RS25140 (5164449) 5164449..5166359 + 1911 WP_004178373.1 PRD domain-containing protein -
KWV87_RS25145 (5166437) 5166437..5166679 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWV87_RS25150 (5166669) 5166669..5166953 + 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWV87_RS25155 (5166957) 5166957..5167421 - 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWV87_RS25160 (5167662) 5167662..5169800 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWV87_RS25165 (5170157) 5170157..5170900 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWV87_RS25170 (5170903) 5170903..5171076 - 174 WP_032408826.1 hypothetical protein -
KWV87_RS25175 (5171206) 5171206..5171469 + 264 WP_228985702.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T209266 WP_004178374.1 NZ_CP079120:5166669-5166953 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209266 NZ_CP103997:2492819-2493067 [Ketogulonicigenium vulgare]
ATGATGATGATTGTTTGGGATGAACCAAAACGCGAAAGCAACCTTGAGAAACACGGGTTAGATTTCGCAGATTTGTCCGA
GGAATTCTTTCTGTCCTCGGTCGTTGTCCCGGCAAAGAACGGGCGTCACATGGCGATAGGAAAACTTGCCGACGGAACGA
TTGCAGTGGTCTTTGCCACACTTGGAACGCAAGGCCTGTCGGTGATCTCGATGCGACATGCCAGCAAAAAGGAAAGGGCG
ATCCTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT209266 WP_002886901.1 NZ_CP079120:5166437-5166679 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209266 NZ_CP103997:2493064-2493354 [Ketogulonicigenium vulgare]
ATGAAAGCCAACAAGCTAACAGAGAAAGAAATCCAACGCCGGATCGCAAGCGATCCGGACGCACCTGAGGCGACAGATGA
CCAGCTTGCGAAGGCTAAGCCGTTCGCCGAGGCGCTGCCCCAACTGGCAGAGAACCTGCGCCGCAACCTTGGCGGCCGCC
CGAAATCCGACAACCCCAAAGTCGCGGTTTCGCTGCGCCTCGATCAAGACGTGATCGAGAAGTTCAAGGCCGCTGGGCCT
GGCTGGCAGTCGCGCATGAACAAAGCCCTGCGCGAAGCTGCGGGGGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References