Detailed information of TA system TA209253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1843868..1845456
• Replicon: chromosome
• Accession: NZ_CP079120
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain WRC03_AI1235PC

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KWV87_RS08730
• Protein ID: WP_004179815.1
• Coordinates: 1844134..1845456 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KWV87_RS08725
• Protein ID: WP_004176198.1
• Coordinates: 1843868..1844134 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWV87_RS08700 (1839018)	1839018..1839941	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
KWV87_RS08705 (1839922)	1839922..1841076	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
KWV87_RS08710 (1841422)	1841422..1842801	+	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
KWV87_RS08715 (1842779)	1842779..1843279	+	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
KWV87_RS08720 (1843276)	1843276..1843602	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
KWV87_RS08725 (1843868)	1843868..1844134	+	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
KWV87_RS08730 (1844134)	1844134..1845456	+	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
KWV87_RS08735 (1845473)	1845473..1846765	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
KWV87_RS08740 (1846907)	1846907..1847911	-	1005	WP_004179822.1	fimbrial protein	-
KWV87_RS08745 (1847899)	1847899..1850400	-	2502	WP_004179823.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T209253 WP_004179815.1 NZ_CP079120:1844134-1845456 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T209253 NZ_CP103974:c4539712-4539539 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT209253 WP_004176198.1 NZ_CP079120:1843868-1844134 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT209253 NZ_CP103974:c4540036-4539740 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG