Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4934146..4934662 Replicon chromosome
Accession NZ_CP079115
Organism Klebsiella pneumoniae subsp. pneumoniae strain WRC01_S465PC

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KWK18_RS24245 Protein ID WP_040216106.1
Coordinates 4934146..4934430 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KWK18_RS24250 Protein ID WP_064162488.1
Coordinates 4934420..4934662 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWK18_RS24220 (4929563) 4929563..4929826 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
KWK18_RS24225 (4929956) 4929956..4930129 + 174 WP_032425422.1 hypothetical protein -
KWK18_RS24230 (4930132) 4930132..4930875 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KWK18_RS24235 (4931232) 4931232..4933370 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
KWK18_RS24240 (4933678) 4933678..4934142 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KWK18_RS24245 (4934146) 4934146..4934430 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KWK18_RS24250 (4934420) 4934420..4934662 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KWK18_RS24255 (4934740) 4934740..4936650 - 1911 WP_023325426.1 PRD domain-containing protein -
KWK18_RS24260 (4936673) 4936673..4937827 - 1155 WP_064162489.1 lactonase family protein -
KWK18_RS24265 (4937894) 4937894..4938634 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T209246 WP_040216106.1 NZ_CP079115:c4934430-4934146 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T209246 NZ_CP103974:c2592829-2592653 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT209246 WP_064162488.1 NZ_CP079115:c4934662-4934420 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT209246 NZ_CP103974:c2592607-2592191 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References