Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 3733992..3734530 Replicon chromosome
Accession NZ_CP079105
Organism Skermania piniformis strain DSM 43998

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KV203_RS17420 Protein ID WP_066474692.1
Coordinates 3733992..3734267 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KV203_RS17425 Protein ID WP_066474695.1
Coordinates 3734270..3734530 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KV203_RS17395 (KV203_17395) 3729142..3729927 - 786 WP_066474767.1 2-keto-4-pentenoate hydratase -
KV203_RS17400 (KV203_17400) 3730043..3731737 + 1695 WP_174522084.1 3-oxosteroid 1-dehydrogenase -
KV203_RS17405 (KV203_17405) 3731737..3732600 + 864 WP_066474684.1 MaoC/PaaZ C-terminal domain-containing protein -
KV203_RS19820 3732816..3732977 + 162 WP_157079973.1 type II toxin-antitoxin system PemK/MazF family toxin -
KV203_RS17415 (KV203_17415) 3733048..3733950 + 903 WP_066474689.1 SDR family NAD(P)-dependent oxidoreductase -
KV203_RS17420 (KV203_17420) 3733992..3734267 - 276 WP_066474692.1 Txe/YoeB family addiction module toxin Toxin
KV203_RS17425 (KV203_17425) 3734270..3734530 - 261 WP_066474695.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KV203_RS17430 (KV203_17430) 3734604..3735440 - 837 WP_066474698.1 antibiotic biosynthesis monooxygenase -
KV203_RS17435 (KV203_17435) 3735660..3736304 + 645 WP_066474700.1 TetR family transcriptional regulator -
KV203_RS17440 (KV203_17440) 3736312..3736569 - 258 WP_157079974.1 hypothetical protein -
KV203_RS17445 (KV203_17445) 3736578..3737717 - 1140 WP_066474703.1 CaiB/BaiF CoA-transferase family protein -
KV203_RS17450 (KV203_17450) 3737746..3738894 - 1149 WP_066474706.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10629.99 Da        Isoelectric Point: 8.0410

>T209228 WP_066474692.1 NZ_CP079105:c3734267-3733992 [Skermania piniformis]
VRLVWDANAWEDYLWWQAQDRKVLGRINALVADIVRNGNEGIGKPEPLKHDFAGYWSRRITDEHRMVYKVVASEGADTEV
RIAACRYHYGR

Download         Length: 276 bp

>T209228 NZ_CP103972:c3830540-3830262 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9717.92 Da        Isoelectric Point: 4.4290

>AT209228 WP_066474695.1 NZ_CP079105:c3734530-3734270 [Skermania piniformis]
MRTMSYSESRARYAEVLDSVVNDREEIVITRAGHEPVVMVSLADFESLRETAYLMRSPANARRLLDAMERLESGAGEERP
LIDTAD

Download         Length: 261 bp

>AT209228 NZ_CP103972:c3830803-3830543 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References