Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3499860..3500645 Replicon chromosome
Accession NZ_CP079097
Organism Methylococcus capsulatus strain KN2

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag KW114_RS16335 Protein ID WP_218797604.1
Coordinates 3499860..3500357 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag KW114_RS16340 Protein ID WP_218797605.1
Coordinates 3500361..3500645 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW114_RS16855 3495053..3495229 + 177 WP_256996431.1 CBS domain-containing protein -
KW114_RS16330 (KW114_16330) 3495645..3499544 + 3900 WP_218797603.1 Ig domain-containing protein -
KW114_RS16335 (KW114_16335) 3499860..3500357 - 498 WP_218797604.1 GNAT family N-acetyltransferase Toxin
KW114_RS16340 (KW114_16340) 3500361..3500645 - 285 WP_218797605.1 DUF1778 domain-containing protein Antitoxin
KW114_RS16345 (KW114_16345) 3501003..3501647 - 645 WP_218797606.1 c-type cytochrome -
KW114_RS16350 (KW114_16350) 3501657..3502862 - 1206 WP_218797607.1 hypothetical protein -
KW114_RS16355 (KW114_16355) 3502876..3504243 - 1368 WP_026045891.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17850.46 Da        Isoelectric Point: 9.5923

>T209225 WP_218797604.1 NZ_CP079097:c3500357-3499860 [Methylococcus capsulatus]
MPLLAPRPLAEHHRTESFASGITSLDDWLKRRALANQSSGASRTFVVCDEHRVIGYYALAAAAIRIQDASSRFRRNMPDP
IPVAILARLAVDQAYQGQGIGRALFRDGARRVVQAADTLGIRGIVVHAISEDAKAFYQALGFDPSPVDAMTLLVTLSDLR
AALPG

Download         Length: 498 bp

>T209225 NZ_CP103972:2102554-2103018 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10662.12 Da        Isoelectric Point: 8.6789

>AT209225 WP_218797605.1 NZ_CP079097:c3500645-3500361 [Methylococcus capsulatus]
MTTTHSQTTKRDSLNIRIKPEDRGLIDRAAKLLGKNRTDFMLDAARRAAEEALLDHAVFMVSPEAYAEFLARLDAPPQPN
ERLRKTVQTSAPWE

Download         Length: 285 bp

>AT209225 NZ_CP103972:2102219-2102554 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References