Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1898131..1899689 Replicon chromosome
Accession NZ_CP079097
Organism Methylococcus capsulatus strain KN2

Toxin (Protein)


Gene name rlegT Uniprot ID -
Locus tag KW114_RS08670 Protein ID WP_218796687.1
Coordinates 1898131..1899057 (-) Length 309 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID -
Locus tag KW114_RS08675 Protein ID WP_218796688.1
Coordinates 1899054..1899689 (-) Length 212 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW114_RS08640 (KW114_08640) 1893561..1894721 + 1161 WP_218796681.1 ABC transporter permease -
KW114_RS08650 (KW114_08650) 1895322..1895573 - 252 WP_218796683.1 hypothetical protein -
KW114_RS08655 (KW114_08655) 1895609..1896106 + 498 WP_218796684.1 DUF2924 domain-containing protein -
KW114_RS08660 (KW114_08660) 1896103..1897278 + 1176 WP_218796685.1 recombinase family protein -
KW114_RS08665 (KW114_08665) 1897646..1898134 - 489 WP_218796686.1 hypothetical protein -
KW114_RS08670 (KW114_08670) 1898131..1899057 - 927 WP_218796687.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KW114_RS08675 (KW114_08675) 1899054..1899689 - 636 WP_218796688.1 AbiEi antitoxin N-terminal domain-containing protein Antitoxin
KW114_RS08685 (KW114_08685) 1900565..1901755 - 1191 WP_010962203.1 PQQ-dependent sugar dehydrogenase -
KW114_RS08690 (KW114_08690) 1901951..1902373 + 423 WP_218796689.1 YeeE/YedE thiosulfate transporter family protein -
KW114_RS08695 (KW114_08695) 1902380..1902865 + 486 WP_218796690.1 YeeE/YedE family protein -
KW114_RS08700 (KW114_08700) 1902935..1903840 - 906 WP_010962206.1 methylenetetrahydromethanopterin dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(36-257)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(20-65)


Sequences

Toxin        


Download         Length: 309 a.a.        Molecular weight: 34644.58 Da        Isoelectric Point: 6.2488

>T209224 WP_218796687.1 NZ_CP079097:c1899057-1898131 [Methylococcus capsulatus]
MNQRNMAASVRARLLNRARETRQDFNLILTRYALERLLYRLSISPHADQFLLKGALLFDLWFDIPHRPTRDADLLGFGSA
EIPHVEAAFRDVCTVELDDGIRFQPDSVHAEEIRKEANYSGVRVTLIGLLDGARCHVQVDVGFGDAVTPGPEAVDYPVML
SEMPAPKLRAYPRYTVIAEKLEALVSLGIANSRMKDYFDLWILSRYTDFDGALLCKAIHATFERRRTPLPDGVPFGLSDE
FAQDRQKQTQWQAFLRKNALVELQISEVVAVLRVFLSPPLDALRQAAAFPQTWLAGSGWASGSEESGR

Download         Length: 927 bp

>T209224 NZ_CP103972:c2059673-2059359 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCAGTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 212 a.a.        Molecular weight: 23676.39 Da        Isoelectric Point: 9.1674

>AT209224 WP_218796688.1 NZ_CP079097:c1899689-1899054 [Methylococcus capsulatus]
MTATDVSQHYDDMDSSHQSILDLAAQRGLIRPRDLNERGLPTVALTRLVRQGLLQRVGRGLYAIPDRTVSEHGALAEVAR
KHPQAIVCLLSALRLHELTTQSPFEVWLAIPNKARAPKMDYPPLRIVRFSGAALTEGVEEHLIDGVPVRVTNVARTVADC
FKFRNKIGLDVALEALQESWRAKRVSMDELWRFAALCRVANVMRPYMESLS

Download         Length: 636 bp

>AT209224 NZ_CP103972:c2059362-2058946 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References