Detailed information of TA system TA209222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2625050..2625627
• Replicon: chromosome
• Accession: NZ_CP079095
• Organism: Methylococcus sp. Mc7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KW115_RS12810
• Protein ID: WP_218806105.1
• Coordinates: 2625050..2625382 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KW115_RS12815
• Protein ID: WP_218806106.1
• Coordinates: 2625370..2625627 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW115_RS12790 (KW115_12790)	2620421..2621737	-	1317	WP_218806101.1	TRZ/ATZ family hydrolase	-
KW115_RS12795 (KW115_12795)	2621897..2623072	+	1176	WP_218806102.1	pyridoxal phosphate-dependent aminotransferase	-
KW115_RS12800 (KW115_12800)	2623097..2624161	+	1065	WP_218806103.1	AI-2E family transporter	-
KW115_RS12805 (KW115_12805)	2624182..2625000	+	819	WP_218806104.1	glutamate racemase	-
KW115_RS12810 (KW115_12810)	2625050..2625382	-	333	WP_218806105.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KW115_RS12815 (KW115_12815)	2625370..2625627	-	258	WP_218806106.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KW115_RS12820 (KW115_12820)	2625741..2626811	+	1071	WP_218806107.1	IS630 family transposase	-
KW115_RS12825 (KW115_12825)	2626950..2628350	-	1401	WP_255556320.1	TolC family outer membrane protein	-
KW115_RS12830 (KW115_12830)	2628592..2629812	+	1221	WP_255556321.1	ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2625741..2626811	1070

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12584.35 Da
• Isoelectric Point: 5.1990

>T209222 WP_218806105.1 NZ_CP079095:c2625382-2625050 [Methylococcus sp. Mc7]
MAEVIWTEPALGDLDAIADYIALDNPEAARSLVQRVFEHVDHLERHPQLGSKPPELKGWGCRQIVEPPCRIFYREDSGHV
FILHVMRAERLLKPELLETRDKETGGTNPF

Nucleotide

• Length: 333 bp

>T209222 NZ_CP103972:1959233-1959610 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9831.45 Da
• Isoelectric Point: 10.5712

>AT209222 WP_218806106.1 NZ_CP079095:c2625627-2625370 [Methylococcus sp. Mc7]
MRTELVTTLKRQATELLSRLARDREPILITQHGVPAAYLVDVETFETLQRRMVLLEGIARGERAIEEGRTLTQAEAKQRM
ARWLK

Nucleotide

• Length: 258 bp

>AT209222 NZ_CP103972:1958809-1959186 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA