Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 2625050..2625627 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag KW115_RS12810 Protein ID WP_218806105.1
Coordinates 2625050..2625382 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KW115_RS12815 Protein ID WP_218806106.1
Coordinates 2625370..2625627 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS12790 (KW115_12790) 2620421..2621737 - 1317 WP_218806101.1 TRZ/ATZ family hydrolase -
KW115_RS12795 (KW115_12795) 2621897..2623072 + 1176 WP_218806102.1 pyridoxal phosphate-dependent aminotransferase -
KW115_RS12800 (KW115_12800) 2623097..2624161 + 1065 WP_218806103.1 AI-2E family transporter -
KW115_RS12805 (KW115_12805) 2624182..2625000 + 819 WP_218806104.1 glutamate racemase -
KW115_RS12810 (KW115_12810) 2625050..2625382 - 333 WP_218806105.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW115_RS12815 (KW115_12815) 2625370..2625627 - 258 WP_218806106.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KW115_RS12820 (KW115_12820) 2625741..2626811 + 1071 WP_218806107.1 IS630 family transposase -
KW115_RS12825 (KW115_12825) 2626950..2628350 - 1401 WP_255556320.1 TolC family outer membrane protein -
KW115_RS12830 (KW115_12830) 2628592..2629812 + 1221 WP_255556321.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2625741..2626811 1070


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12584.35 Da        Isoelectric Point: 5.1990

>T209222 WP_218806105.1 NZ_CP079095:c2625382-2625050 [Methylococcus sp. Mc7]
MAEVIWTEPALGDLDAIADYIALDNPEAARSLVQRVFEHVDHLERHPQLGSKPPELKGWGCRQIVEPPCRIFYREDSGHV
FILHVMRAERLLKPELLETRDKETGGTNPF

Download         Length: 333 bp

>T209222 NZ_CP103972:1959233-1959610 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9831.45 Da        Isoelectric Point: 10.5712

>AT209222 WP_218806106.1 NZ_CP079095:c2625627-2625370 [Methylococcus sp. Mc7]
MRTELVTTLKRQATELLSRLARDREPILITQHGVPAAYLVDVETFETLQRRMVLLEGIARGERAIEEGRTLTQAEAKQRM
ARWLK

Download         Length: 258 bp

>AT209222 NZ_CP103972:1958809-1959186 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGAAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References