Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2466845..2467630 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag KW115_RS12140 Protein ID WP_218805979.1
Coordinates 2466845..2467342 (-) Length 166 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID -
Locus tag KW115_RS12145 Protein ID WP_218805980.1
Coordinates 2467346..2467630 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS12120 (KW115_12120) 2463581..2464978 + 1398 WP_218805975.1 FAD/NAD(P)-binding protein -
KW115_RS12125 (KW115_12125) 2464983..2465204 - 222 WP_218805976.1 type II toxin-antitoxin system VapC family toxin -
KW115_RS12130 (KW115_12130) 2465356..2465574 - 219 WP_218805977.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
KW115_RS12135 (KW115_12135) 2465990..2466592 + 603 WP_218805978.1 putative Ig domain-containing protein -
KW115_RS12140 (KW115_12140) 2466845..2467342 - 498 WP_218805979.1 GNAT family N-acetyltransferase Toxin
KW115_RS12145 (KW115_12145) 2467346..2467630 - 285 WP_218805980.1 DUF1778 domain-containing protein Antitoxin
KW115_RS12150 (KW115_12150) 2467975..2468619 - 645 WP_218805981.1 c-type cytochrome -
KW115_RS12155 (KW115_12155) 2468629..2469834 - 1206 WP_218805982.1 hypothetical protein -
KW115_RS12160 (KW115_12160) 2469847..2471214 - 1368 WP_218805983.1 cytochrome c -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 17806.41 Da        Isoelectric Point: 9.5923

>T209220 WP_218805979.1 NZ_CP079095:c2467342-2466845 [Methylococcus sp. Mc7]
MPLLAPRPLAEHHRTESFASGITSLDDWLKRRALANQSSGASRTFVVCDEHRVIGYYALAAGAIRIQDASGRFRRNMPDP
IPVAILARLAVDQAYQGQGIGRALFRDGARRVVQAADTLGIRGIVVHAISEDAKAFYQALGFDPSPVDAMTLLVTLSDLR
AALPG

Download         Length: 498 bp

>T209220 NZ_CP103972:c1643577-1643242 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10709.18 Da        Isoelectric Point: 9.9860

>AT209220 WP_218805980.1 NZ_CP079095:c2467630-2467346 [Methylococcus sp. Mc7]
MTTTHSQTTRRDSLNIRIKPEDRGLIDRAAKLLGKNRTDFMLDAARRAAEEALLDRAVFVVSPEAYAEFLARLDAPPQPN
ERLRKTMQTSAPWE

Download         Length: 285 bp

>AT209220 NZ_CP103972:c1643825-1643577 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References