Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1843005..1844550 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag KW115_RS09160 Protein ID WP_218808792.1
Coordinates 1843005..1844300 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name HipB2 Uniprot ID -
Locus tag KW115_RS09165 Protein ID WP_218808793.1
Coordinates 1844290..1844550 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS09145 (KW115_09145) 1839873..1840223 - 351 WP_218808790.1 DUF2793 domain-containing protein -
KW115_RS09150 (KW115_09150) 1840223..1841863 - 1641 WP_218808791.1 phage tail protein -
KW115_RS09155 (KW115_09155) 1841834..1842487 + 654 Protein_1802 transposase -
KW115_RS09160 (KW115_09160) 1843005..1844300 - 1296 WP_218808792.1 type II toxin-antitoxin system HipA family toxin Toxin
KW115_RS09165 (KW115_09165) 1844290..1844550 - 261 WP_218808793.1 helix-turn-helix transcriptional regulator Antitoxin
KW115_RS09170 (KW115_09170) 1844903..1845493 + 591 WP_255556676.1 hypothetical protein -
KW115_RS09175 (KW115_09175) 1845510..1846916 - 1407 WP_218808794.1 PLP-dependent aminotransferase family protein -
KW115_RS09180 (KW115_09180) 1847073..1847549 + 477 WP_218809025.1 cupin domain-containing protein -
KW115_RS09185 (KW115_09185) 1847533..1848339 + 807 WP_218808795.1 nuclear transport factor 2 family protein -
KW115_RS09190 (KW115_09190) 1848357..1848965 + 609 WP_218808796.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-102)

Antitoxin

Transcription regulator, HipB-like

(9-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 47512.49 Da        Isoelectric Point: 6.4310

>T209219 WP_218808792.1 NZ_CP079095:c1844300-1843005 [Methylococcus sp. Mc7]
MAHELEVWLFTDRVGTLALVDGRLNFCYAPDWLSHKDAVALSASLPLQAEPFDDRKARPFFAGLLPEGQMRRLIAQQFQV
SGQNDFALLDHIGGECAGAVTFLEPGQALPVPTRNDDVQWLSDDEVVAILDELPRRPMLAGKDGLRLSLAGAQDKLPVVF
DGARIGLPLNGTPSSHILKPAIHAVEDSVINEGFCMALADAMQLKPAKSKVHQVLDRSFLLVERYDRLIDAQGHRQRLHQ
EDFCQAMGVVPEMKYQNEGGPDLAQCFDLVRSATRPSAPQVLRLLDYVIFNALIGNHDAHAKNFSLLYAGKAPVLAPFYD
TLSTAVYPAMTPKMAMKIGSKYKFSEVQARHWEQFAEGVGFTKAQAKRRILELAKSLPATARKLQSAPERGFAGNAVVER
ITALIEQRCTLTIRRLTDPAAENDAPDEPSV

Download         Length: 1296 bp

>T209219 NZ_CP103972:c831567-831316 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 8985.24 Da        Isoelectric Point: 5.7735

>AT209219 WP_218808793.1 NZ_CP079095:c1844550-1844290 [Methylococcus sp. Mc7]
MTSIRSPQQLGDALRAARKQLGLTQPQLALAAGVGVRFIVDLESGKPTLRLENVLRVIDALGGEVQLSGLPSVAADEQRE
GGDHGA

Download         Length: 261 bp

>AT209219 NZ_CP103972:c831319-831065 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References