Detailed information of TA system TA209217

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1623604..1624157
• Replicon: chromosome
• Accession: NZ_CP079095
• Organism: Methylococcus sp. Mc7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: KW115_RS08085
• Protein ID: WP_218808616.1
• Coordinates: 1623604..1623915 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: KW115_RS08090
• Protein ID: WP_218808617.1
• Coordinates: 1623915..1624157 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW115_RS08055 (KW115_08055)	1619085..1619681	+	597	WP_255556660.1	hypothetical protein	-
KW115_RS08060 (KW115_08060)	1619784..1620158	+	375	WP_255556662.1	DUF3592 domain-containing protein	-
KW115_RS08065 (KW115_08065)	1620496..1621227	+	732	WP_255556663.1	DUF4410 domain-containing protein	-
KW115_RS08070 (KW115_08070)	1621246..1621506	-	261	WP_218808613.1	zinc ribbon domain-containing protein	-
KW115_RS08075 (KW115_08075)	1621624..1622220	+	597	WP_218808614.1	nicotinamidase	-
KW115_RS08080 (KW115_08080)	1622217..1623563	+	1347	WP_218808615.1	nicotinate phosphoribosyltransferase	-
KW115_RS08085 (KW115_08085)	1623604..1623915	-	312	WP_218808616.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KW115_RS08090 (KW115_08090)	1623915..1624157	-	243	WP_218808617.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
KW115_RS08095 (KW115_08095)	1624357..1625112	-	756	WP_218808618.1	hypothetical protein	-
KW115_RS08100 (KW115_08100)	1625258..1626691	+	1434	WP_218807097.1	IS1380 family transposase	-
KW115_RS08105 (KW115_08105)	1627001..1627645	+	645	WP_218808619.1	hypothetical protein	-
KW115_RS08110 (KW115_08110)	1627633..1628529	+	897	WP_218808620.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1625258..1626691	1433

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (4-69)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11659.34 Da
• Isoelectric Point: 9.2322

>T209217 WP_218808616.1 NZ_CP079095:c1623915-1623604 [Methylococcus sp. Mc7]
MPRFVLTNKAKADLKSIGRHTADTWGREQRNRYLASLDGAFHEPAADPFKGGDCGAVRPGYRKLRVGRHIVFYRLLNAGC
IEIVRVLHERMDVECHLQGPDTD

Nucleotide

• Length: 312 bp

>T209217 NZ_CP103972:c629898-629795 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8974.98 Da
• Isoelectric Point: 4.8550

>AT209217 WP_218808617.1 NZ_CP079095:c1624157-1623915 [Methylococcus sp. Mc7]
MHKNTSVTLGQHFDQFIAQQITKGRFASASEVIRAGLRVLEERETRLEALARALKDGEDSGRADYSLEGLIEELDRENVS

Nucleotide

• Length: 243 bp

>AT209217 NZ_CP103972:629757-630028 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT