Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1623604..1624157 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag KW115_RS08085 Protein ID WP_218808616.1
Coordinates 1623604..1623915 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag KW115_RS08090 Protein ID WP_218808617.1
Coordinates 1623915..1624157 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS08055 (KW115_08055) 1619085..1619681 + 597 WP_255556660.1 hypothetical protein -
KW115_RS08060 (KW115_08060) 1619784..1620158 + 375 WP_255556662.1 DUF3592 domain-containing protein -
KW115_RS08065 (KW115_08065) 1620496..1621227 + 732 WP_255556663.1 DUF4410 domain-containing protein -
KW115_RS08070 (KW115_08070) 1621246..1621506 - 261 WP_218808613.1 zinc ribbon domain-containing protein -
KW115_RS08075 (KW115_08075) 1621624..1622220 + 597 WP_218808614.1 nicotinamidase -
KW115_RS08080 (KW115_08080) 1622217..1623563 + 1347 WP_218808615.1 nicotinate phosphoribosyltransferase -
KW115_RS08085 (KW115_08085) 1623604..1623915 - 312 WP_218808616.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW115_RS08090 (KW115_08090) 1623915..1624157 - 243 WP_218808617.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
KW115_RS08095 (KW115_08095) 1624357..1625112 - 756 WP_218808618.1 hypothetical protein -
KW115_RS08100 (KW115_08100) 1625258..1626691 + 1434 WP_218807097.1 IS1380 family transposase -
KW115_RS08105 (KW115_08105) 1627001..1627645 + 645 WP_218808619.1 hypothetical protein -
KW115_RS08110 (KW115_08110) 1627633..1628529 + 897 WP_218808620.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1625258..1626691 1433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-69)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11659.34 Da        Isoelectric Point: 9.2322

>T209217 WP_218808616.1 NZ_CP079095:c1623915-1623604 [Methylococcus sp. Mc7]
MPRFVLTNKAKADLKSIGRHTADTWGREQRNRYLASLDGAFHEPAADPFKGGDCGAVRPGYRKLRVGRHIVFYRLLNAGC
IEIVRVLHERMDVECHLQGPDTD

Download         Length: 312 bp

>T209217 NZ_CP103972:c629898-629795 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8974.98 Da        Isoelectric Point: 4.8550

>AT209217 WP_218808617.1 NZ_CP079095:c1624157-1623915 [Methylococcus sp. Mc7]
MHKNTSVTLGQHFDQFIAQQITKGRFASASEVIRAGLRVLEERETRLEALARALKDGEDSGRADYSLEGLIEELDRENVS

Download         Length: 243 bp

>AT209217 NZ_CP103972:629757-630028 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References