Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1590689..1591797 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KW115_RS07880 Protein ID WP_218808582.1
Coordinates 1590689..1591441 (-) Length 251 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KW115_RS07885 Protein ID WP_218808583.1
Coordinates 1591438..1591797 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS07870 (KW115_07870) 1586466..1588013 - 1548 WP_218808581.1 DUF839 domain-containing protein -
KW115_RS07875 (KW115_07875) 1589010..1590443 + 1434 WP_218807097.1 IS1380 family transposase -
KW115_RS07880 (KW115_07880) 1590689..1591441 - 753 WP_218808582.1 RES family NAD+ phosphorylase Toxin
KW115_RS07885 (KW115_07885) 1591438..1591797 - 360 WP_218808583.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
KW115_RS07890 (KW115_07890) 1592000..1592344 + 345 WP_218808584.1 phenylpyruvate tautomerase MIF-related protein -
KW115_RS07895 (KW115_07895) 1592398..1593237 - 840 WP_218809008.1 shikimate dehydrogenase -
KW115_RS07900 (KW115_07900) 1593234..1594238 - 1005 WP_218808585.1 porphobilinogen synthase -
KW115_RS07905 (KW115_07905) 1594352..1595005 + 654 WP_218808586.1 ABC transporter substrate-binding protein -
KW115_RS07910 (KW115_07910) 1595000..1595914 - 915 WP_218808587.1 oxygen-dependent coproporphyrinogen oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-206)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(69-117)


Sequences

Toxin        


Download         Length: 251 a.a.        Molecular weight: 27896.63 Da        Isoelectric Point: 5.3200

>T209216 WP_218808582.1 NZ_CP079095:c1591441-1590689 [Methylococcus sp. Mc7]
MSAIWAACRDQAPLGPLHGHLYRMVESQEQVATYRIVSSLEEQALLEELLETSKPPPPETAGDFHYLLTTPFRYPPLRHG
SRFGRRHEPGLFYGSATVDTMLAEVAYYRFVFWQGMETPPQTPIVTQHTVFSARYACGRGLKLQDPPFDAWRATLTDPRH
YAPTQDLGSAMREAGVQAFEYLSARDPAAGINVALFEPAALASQRPIECQNWLAETSGEHVAFLGEARQIRGFELETFLV
EGMLPAPAVC

Download         Length: 753 bp

>T209216 NZ_CP103972:c318849-318562 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 12942.99 Da        Isoelectric Point: 10.6082

>AT209216 WP_218808583.1 NZ_CP079095:c1591797-1591438 [Methylococcus sp. Mc7]
MNTVAKAKPEPSSVLGHAFLEAGRKLGLSQSVLEVTIARNRSSISRNGIDPDSKSGELALLLIRIYRSLFALMGGDEAQM
AHWMKTRNRHTGGIPAEQIRSVQGLVGVVEYLDAMRGKI

Download         Length: 360 bp

>AT209216 NZ_CP103972:c319088-318849 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References