Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-Phd
Location 1278627..1279366 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KW115_RS06330 Protein ID WP_218808312.1
Coordinates 1278627..1279052 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KW115_RS06335 Protein ID WP_218808313.1
Coordinates 1279118..1279366 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS06310 (KW115_06310) 1273772..1274281 - 510 WP_218808308.1 hypothetical protein -
KW115_RS06315 (KW115_06315) 1274278..1275312 - 1035 WP_218808309.1 ATP-binding protein -
KW115_RS06320 (KW115_06320) 1275309..1278098 - 2790 WP_218808310.1 DNA methyltransferase -
KW115_RS06325 (KW115_06325) 1278138..1278557 - 420 WP_218808311.1 four helix bundle protein -
KW115_RS06330 (KW115_06330) 1278627..1279052 - 426 WP_218808312.1 type II toxin-antitoxin system VapC family toxin Toxin
KW115_RS06335 (KW115_06335) 1279118..1279366 - 249 WP_218808313.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KW115_RS06340 (KW115_06340) 1279422..1283219 - 3798 WP_218808314.1 DUF6079 family protein -
KW115_RS06345 (KW115_06345) 1283233..1283772 - 540 WP_218808315.1 BREX-3 system P-loop-containing protein BrxF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15696.99 Da        Isoelectric Point: 5.7160

>T209215 WP_218808312.1 NZ_CP079095:c1279052-1278627 [Methylococcus sp. Mc7]
VSNGGGFLLDTNIVSELRRKQPEPRVLRWFEQVSDDKLYLSVLTIGEIRRGIARLTDPAQQHRLTDWLEGTLFPWLGSQL
LPVNLAVAECWGRLCGAAGRPLPTIDSLLAATAVEHGLTLVTRNAADFQFAGLQVFNPWEF

Download         Length: 426 bp

>T209215 NZ_CP103972:c262975-261653 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9560.02 Da        Isoelectric Point: 4.6768

>AT209215 WP_218808313.1 NZ_CP079095:c1279366-1279118 [Methylococcus sp. Mc7]
MREWALQDAKARLSEVVRLAMEHEPQEITLRGEPAVVVLSMEDYRRLVHPKPSFVELIRSSPLMDVDIDLTREQSMTREV
DL

Download         Length: 249 bp

>AT209215 NZ_CP103972:c263241-262975 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References