Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 84034..84664 Replicon chromosome
Accession NZ_CP079095
Organism Methylococcus sp. Mc7

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KW115_RS00420 Protein ID WP_218807270.1
Coordinates 84254..84664 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag KW115_RS00415 Protein ID WP_218807269.1
Coordinates 84034..84267 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW115_RS00400 (KW115_00400) 79079..80851 - 1773 WP_255556522.1 calx-beta domain-containing protein -
KW115_RS00405 (KW115_00405) 81141..82847 - 1707 WP_218807267.1 multicopper oxidase domain-containing protein -
KW115_RS00410 (KW115_00410) 83054..83263 - 210 WP_218807268.1 hypothetical protein -
KW115_RS00415 (KW115_00415) 84034..84267 + 234 WP_218807269.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
KW115_RS00420 (KW115_00420) 84254..84664 + 411 WP_218807270.1 PIN domain-containing protein Toxin
KW115_RS00425 (KW115_00425) 84842..85378 + 537 WP_218807271.1 copper resistance protein NlpE -
KW115_RS00430 (KW115_00430) 85557..85811 + 255 WP_218807272.1 DUF504 domain-containing protein -
KW115_RS00435 (KW115_00435) 85863..86819 + 957 WP_218807273.1 radical SAM protein -
KW115_RS00440 (KW115_00440) 86826..87644 - 819 WP_218807274.1 CheR family methyltransferase -
KW115_RS00445 (KW115_00445) 87801..89549 + 1749 WP_218807275.1 proline--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15179.43 Da        Isoelectric Point: 4.6051

>T209214 WP_218807270.1 NZ_CP079095:84254-84664 [Methylococcus sp. Mc7]
MPATNAFIDTNVLLYFLSDDTDKADRAEAIVRNGGRISVQVLNEMASVARRKLAMPWEEINEVLTLIRTLCPVEPITVAT
HDRGRWIAERYGLSVYDAMILAAALLAGCETLYSEDMQGGQLIEGRLRIHNPFSEI

Download         Length: 411 bp

>T209214 NZ_CP103972:180508-180684 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8618.82 Da        Isoelectric Point: 5.8214

>AT209214 WP_218807269.1 NZ_CP079095:84034-84267 [Methylococcus sp. Mc7]
MQVSKWGNSLAIRIPASVVEALDLHEGDDIQVVVADERVFALAKQPGKEALLERLRRFRGKLPTGFVFDRDDANARD

Download         Length: 234 bp

>AT209214 NZ_CP103972:180730-181146 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References