209213

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2477109..2477632 Replicon chromosome
Accession NZ_CP078521
Organism Staphylococcus aureus strain ATCC 29213

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag KWH15_RS12380 Protein ID WP_000074049.1
Coordinates 2477109..2477375 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag KWH15_RS12385 Protein ID WP_000587616.1
Coordinates 2477375..2477632 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KWH15_RS12360 (2472416) 2472416..2473603 - 1188 WP_000026189.1 MFS transporter -
KWH15_RS12365 (2473999) 2473999..2474775 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
KWH15_RS12370 (2474768) 2474768..2475430 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
KWH15_RS12375 (2475678) 2475678..2476754 - 1077 WP_001076673.1 M42 family metallopeptidase -
KWH15_RS12380 (2477109) 2477109..2477375 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
KWH15_RS12385 (2477375) 2477375..2477632 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KWH15_RS12390 (2477991) 2477991..2478446 + 456 WP_000732076.1 DUF1307 domain-containing protein -
KWH15_RS12395 (2478614) 2478614..2480191 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
KWH15_RS12400 (2480386) 2480386..2481135 + 750 WP_000072462.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T209213 WP_000074049.1 NZ_CP078521:c2477375-2477109 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T209213 NZ_CP103965:5887301-5887945 [Pseudomonas sp. N3-W]
ATGAACTACACCAGTCTGAATCCAGAGAAGGCTCTGATTTGGCGTATCATCCACCGCGATAACCTGCTTTGGATTCTGGA
CAATGGCCTGCATTGCGCCAGCTCGGACGTGCAGGCACCGCAGTACGTGAATATTGGCAACGCTGACTTGATCGACAAGC
GTCGCAATCGCTGTGTTCCTATTGCTCCAGCGGGCGTATTGGCCGACTACGTACCCTTCTATTTCACTCCCTTCTCTGTG
ATGATGAAAAATATTCATTCTGGATGGAGTGTTCAGCAGCGCAGCAACGACGAGATCGTGATTCTGGTCTCCAGCCTGTA
CCGCGTCGAACAGCTTGGCCTACCGTTTGTCTTCACAAACGCACATGCCTACCCGGATTGGACAGACTATTACAGCGATC
TGGCGAATCTCGGAGAGGTCGATTGGTCTATTCTTCAACGACGCGACTTCAAACGTGACTCTGATGACCCTCGAAAGATG
GAGCGTTATCAGGCCGAAGCGCTGATTCACCATCACCTACCGATTACAGGACTCCTTGGCATCATGTGTTACAACGATGC
AGTGAAAGAGCGCATAGAGCAGGACGTGGCCGCTAGAGGCTTAGCGTTGTCTGTTCATGCACGTCCGGGATGGTATTTCC
AATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT209213 WP_000587616.1 NZ_CP078521:c2477632-2477375 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT209213 NZ_CP103965:5887942-5889030 [Pseudomonas sp. N3-W]
ATGATCAGATTTACCCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTCGTCAACACGGTGAATACCGTAGGCGTGAT
GGGCAAAGGTATCGCGCTGATGTTCAAAGAGCGCTTCGCGGAGAATTACCGTATCTATTCGGCAGCCTGCAAGGCTGGTG
AGGTGGAGACAGGCAAGGTTCACGTAACGGCAGCCAACGAGCTCGACGGTCCTCGCTGGATCGTAAACTTTCCTACCAAA
CGTCACTGGCGATCGCCATCGCAGATGGCATGGATAACCGAAGGTTTACACGATCTGCGTCGCTTCCTGATTGAAAACAA
CGTGAAGTCCGTGGCGGTTCCACCGCTAGGTGCCGGGAACGGTGGTTTGAAATGGCCAGAAGTTCGCGAACAGATTGTTA
ATGTCTTGAGTGATCTAGATGTCGACGTGTTGGTATTTGAGCCGTCCAATCAGTATCTGAACGTCGCCAAACGTAGCGGC
GTGGAACAGCTCACCCCTGCTCGCGCACTCATTGCCGAACTGGTTCGGCGTTACTGGGTTTTGGGCATGGAATGTAGCCT
GCTTGAGATTCAGAAGCTGGCCTGGTTCCTGGAGCGTGCGATAGAGAAACTGCCGAACGCCACAAACCCGCTGGATCTTA
AGTTTGTTGCTCATAAATACGGGCCGTATGCCAATCGATTGGAGCATCTGCTCAATAACCTGGATGGCAGCTACCTGCAT
TGCGACAAGCGCATCAGCGATGCGGGTATCAGCGATGTGATCTGGTTTGACCAAGAGCGCAAAGCCTTTTTGCAAACCTA
CCTCAAGACAGAGGCCAAGGAGTATTCACAAGCGTTGGAGCGCACTGCTAAGTTGATCGACGGCTTCGAGTCGCCATTCG
GCATGGAGTTGCTGGCGACGGTCGATTGGTTGCTAAGTCAGGAGGGAATATCCCCGACTGTTCCTGCTGTGCGCGAAGCG
CTGAAGCACTGGGATGGTGGAGCCGGTGCTGCCGCTCGCAAGAGCAGACTGTTTGACGACTCAGCGCTTGATATTGCTCT
CAAACGCCTGACCTCCAGTAGCTTCAGACCTGAAGTGGCAGCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References