Detailed information of TA system
Overview
TA module
Type | II | Classification (family/domain) | relE-yefM/Txe-RelB |
Location | 2477109..2477632 | Replicon | chromosome |
Accession | NZ_CP078521 | ||
Organism | Staphylococcus aureus strain ATCC 29213 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A3A5LQI3 |
Locus tag | KWH15_RS12380 | Protein ID | WP_000074049.1 |
Coordinates | 2477109..2477375 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | W8TQT5 |
Locus tag | KWH15_RS12385 | Protein ID | WP_000587616.1 |
Coordinates | 2477375..2477632 (-) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KWH15_RS12360 (2472416) | 2472416..2473603 | - | 1188 | WP_000026189.1 | MFS transporter | - |
KWH15_RS12365 (2473999) | 2473999..2474775 | - | 777 | WP_000072149.1 | iron export ABC transporter permease subunit FetB | - |
KWH15_RS12370 (2474768) | 2474768..2475430 | - | 663 | WP_000923526.1 | ATP-binding cassette domain-containing protein | - |
KWH15_RS12375 (2475678) | 2475678..2476754 | - | 1077 | WP_001076673.1 | M42 family metallopeptidase | - |
KWH15_RS12380 (2477109) | 2477109..2477375 | - | 267 | WP_000074049.1 | Txe/YoeB family addiction module toxin | Toxin |
KWH15_RS12385 (2477375) | 2477375..2477632 | - | 258 | WP_000587616.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
KWH15_RS12390 (2477991) | 2477991..2478446 | + | 456 | WP_000732076.1 | DUF1307 domain-containing protein | - |
KWH15_RS12395 (2478614) | 2478614..2480191 | - | 1578 | WP_000143494.1 | FMN-binding glutamate synthase family protein | - |
KWH15_RS12400 (2480386) | 2480386..2481135 | + | 750 | WP_000072462.1 | CPBP family lipoprotein N-acylation protein LnsB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10676.24 Da Isoelectric Point: 10.1597
>T209213 WP_000074049.1 NZ_CP078521:c2477375-2477109 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD
Download Length: 267 bp
>T209213 NZ_CP103965:5887301-5887945 [Pseudomonas sp. N3-W]
ATGAACTACACCAGTCTGAATCCAGAGAAGGCTCTGATTTGGCGTATCATCCACCGCGATAACCTGCTTTGGATTCTGGA
CAATGGCCTGCATTGCGCCAGCTCGGACGTGCAGGCACCGCAGTACGTGAATATTGGCAACGCTGACTTGATCGACAAGC
GTCGCAATCGCTGTGTTCCTATTGCTCCAGCGGGCGTATTGGCCGACTACGTACCCTTCTATTTCACTCCCTTCTCTGTG
ATGATGAAAAATATTCATTCTGGATGGAGTGTTCAGCAGCGCAGCAACGACGAGATCGTGATTCTGGTCTCCAGCCTGTA
CCGCGTCGAACAGCTTGGCCTACCGTTTGTCTTCACAAACGCACATGCCTACCCGGATTGGACAGACTATTACAGCGATC
TGGCGAATCTCGGAGAGGTCGATTGGTCTATTCTTCAACGACGCGACTTCAAACGTGACTCTGATGACCCTCGAAAGATG
GAGCGTTATCAGGCCGAAGCGCTGATTCACCATCACCTACCGATTACAGGACTCCTTGGCATCATGTGTTACAACGATGC
AGTGAAAGAGCGCATAGAGCAGGACGTGGCCGCTAGAGGCTTAGCGTTGTCTGTTCATGCACGTCCGGGATGGTATTTCC
AATGA
ATGAACTACACCAGTCTGAATCCAGAGAAGGCTCTGATTTGGCGTATCATCCACCGCGATAACCTGCTTTGGATTCTGGA
CAATGGCCTGCATTGCGCCAGCTCGGACGTGCAGGCACCGCAGTACGTGAATATTGGCAACGCTGACTTGATCGACAAGC
GTCGCAATCGCTGTGTTCCTATTGCTCCAGCGGGCGTATTGGCCGACTACGTACCCTTCTATTTCACTCCCTTCTCTGTG
ATGATGAAAAATATTCATTCTGGATGGAGTGTTCAGCAGCGCAGCAACGACGAGATCGTGATTCTGGTCTCCAGCCTGTA
CCGCGTCGAACAGCTTGGCCTACCGTTTGTCTTCACAAACGCACATGCCTACCCGGATTGGACAGACTATTACAGCGATC
TGGCGAATCTCGGAGAGGTCGATTGGTCTATTCTTCAACGACGCGACTTCAAACGTGACTCTGATGACCCTCGAAAGATG
GAGCGTTATCAGGCCGAAGCGCTGATTCACCATCACCTACCGATTACAGGACTCCTTGGCATCATGTGTTACAACGATGC
AGTGAAAGAGCGCATAGAGCAGGACGTGGCCGCTAGAGGCTTAGCGTTGTCTGTTCATGCACGTCCGGGATGGTATTTCC
AATGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9774.73 Da Isoelectric Point: 4.1353
>AT209213 WP_000587616.1 NZ_CP078521:c2477632-2477375 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL
Download Length: 258 bp
>AT209213 NZ_CP103965:5887942-5889030 [Pseudomonas sp. N3-W]
ATGATCAGATTTACCCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTCGTCAACACGGTGAATACCGTAGGCGTGAT
GGGCAAAGGTATCGCGCTGATGTTCAAAGAGCGCTTCGCGGAGAATTACCGTATCTATTCGGCAGCCTGCAAGGCTGGTG
AGGTGGAGACAGGCAAGGTTCACGTAACGGCAGCCAACGAGCTCGACGGTCCTCGCTGGATCGTAAACTTTCCTACCAAA
CGTCACTGGCGATCGCCATCGCAGATGGCATGGATAACCGAAGGTTTACACGATCTGCGTCGCTTCCTGATTGAAAACAA
CGTGAAGTCCGTGGCGGTTCCACCGCTAGGTGCCGGGAACGGTGGTTTGAAATGGCCAGAAGTTCGCGAACAGATTGTTA
ATGTCTTGAGTGATCTAGATGTCGACGTGTTGGTATTTGAGCCGTCCAATCAGTATCTGAACGTCGCCAAACGTAGCGGC
GTGGAACAGCTCACCCCTGCTCGCGCACTCATTGCCGAACTGGTTCGGCGTTACTGGGTTTTGGGCATGGAATGTAGCCT
GCTTGAGATTCAGAAGCTGGCCTGGTTCCTGGAGCGTGCGATAGAGAAACTGCCGAACGCCACAAACCCGCTGGATCTTA
AGTTTGTTGCTCATAAATACGGGCCGTATGCCAATCGATTGGAGCATCTGCTCAATAACCTGGATGGCAGCTACCTGCAT
TGCGACAAGCGCATCAGCGATGCGGGTATCAGCGATGTGATCTGGTTTGACCAAGAGCGCAAAGCCTTTTTGCAAACCTA
CCTCAAGACAGAGGCCAAGGAGTATTCACAAGCGTTGGAGCGCACTGCTAAGTTGATCGACGGCTTCGAGTCGCCATTCG
GCATGGAGTTGCTGGCGACGGTCGATTGGTTGCTAAGTCAGGAGGGAATATCCCCGACTGTTCCTGCTGTGCGCGAAGCG
CTGAAGCACTGGGATGGTGGAGCCGGTGCTGCCGCTCGCAAGAGCAGACTGTTTGACGACTCAGCGCTTGATATTGCTCT
CAAACGCCTGACCTCCAGTAGCTTCAGACCTGAAGTGGCAGCCTGTTAA
ATGATCAGATTTACCCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTCGTCAACACGGTGAATACCGTAGGCGTGAT
GGGCAAAGGTATCGCGCTGATGTTCAAAGAGCGCTTCGCGGAGAATTACCGTATCTATTCGGCAGCCTGCAAGGCTGGTG
AGGTGGAGACAGGCAAGGTTCACGTAACGGCAGCCAACGAGCTCGACGGTCCTCGCTGGATCGTAAACTTTCCTACCAAA
CGTCACTGGCGATCGCCATCGCAGATGGCATGGATAACCGAAGGTTTACACGATCTGCGTCGCTTCCTGATTGAAAACAA
CGTGAAGTCCGTGGCGGTTCCACCGCTAGGTGCCGGGAACGGTGGTTTGAAATGGCCAGAAGTTCGCGAACAGATTGTTA
ATGTCTTGAGTGATCTAGATGTCGACGTGTTGGTATTTGAGCCGTCCAATCAGTATCTGAACGTCGCCAAACGTAGCGGC
GTGGAACAGCTCACCCCTGCTCGCGCACTCATTGCCGAACTGGTTCGGCGTTACTGGGTTTTGGGCATGGAATGTAGCCT
GCTTGAGATTCAGAAGCTGGCCTGGTTCCTGGAGCGTGCGATAGAGAAACTGCCGAACGCCACAAACCCGCTGGATCTTA
AGTTTGTTGCTCATAAATACGGGCCGTATGCCAATCGATTGGAGCATCTGCTCAATAACCTGGATGGCAGCTACCTGCAT
TGCGACAAGCGCATCAGCGATGCGGGTATCAGCGATGTGATCTGGTTTGACCAAGAGCGCAAAGCCTTTTTGCAAACCTA
CCTCAAGACAGAGGCCAAGGAGTATTCACAAGCGTTGGAGCGCACTGCTAAGTTGATCGACGGCTTCGAGTCGCCATTCG
GCATGGAGTTGCTGGCGACGGTCGATTGGTTGCTAAGTCAGGAGGGAATATCCCCGACTGTTCCTGCTGTGCGCGAAGCG
CTGAAGCACTGGGATGGTGGAGCCGGTGCTGCCGCTCGCAAGAGCAGACTGTTTGACGACTCAGCGCTTGATATTGCTCT
CAAACGCCTGACCTCCAGTAGCTTCAGACCTGAAGTGGCAGCCTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3A5LQI3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | W8TQT5 |