Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsdAT/- |
| Location | 2101528..2102042 | Replicon | chromosome |
| Accession | NZ_CP078521 | ||
| Organism | Staphylococcus aureus strain ATCC 29213 | ||
Toxin (Protein)
| Gene name | TsdT | Uniprot ID | T1YA99 |
| Locus tag | KWH15_RS10420 | Protein ID | WP_000581792.1 |
| Coordinates | 2101528..2101737 (-) | Length | 70 a.a. |
Antitoxin (Protein)
| Gene name | TsdA | Uniprot ID | W8UW13 |
| Locus tag | KWH15_RS10425 | Protein ID | WP_000138932.1 |
| Coordinates | 2101749..2102042 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWH15_RS10400 (2097036) | 2097036..2098394 | - | 1359 | WP_000611464.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
| KWH15_RS10405 (2098409) | 2098409..2099479 | - | 1071 | WP_000159631.1 | D-alanine--D-alanine ligase | - |
| KWH15_RS10410 (2099797) | 2099797..2100999 | + | 1203 | WP_001109939.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
| KWH15_RS10415 (2101263) | 2101263..2101400 | - | 138 | WP_000828354.1 | Lmo0850 family protein | - |
| KWH15_RS10420 (2101528) | 2101528..2101737 | - | 210 | WP_000581792.1 | heavy metal-associated domain-containing protein | Toxin |
| KWH15_RS10425 (2101749) | 2101749..2102042 | - | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
| KWH15_RS10430 (2102208) | 2102208..2103692 | + | 1485 | WP_000571549.1 | cardiolipin synthase | - |
| KWH15_RS10435 (2103720) | 2103720..2104367 | + | 648 | WP_001187630.1 | HD domain-containing protein | - |
| KWH15_RS10440 (2105280) | 2105280..2106152 | - | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
| KWH15_RS10445 (2106238) | 2106238..2106879 | - | 642 | WP_000483153.1 | thiamine phosphate synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7843.77 Da Isoelectric Point: 4.1008
>T209207 WP_000581792.1 NZ_CP078521:c2101737-2101528 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T209207 NZ_CP103964:c2202745-2201882 [Staphylococcus hyicus]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTAAG
CGATCAAGGCTATAACTTGGTGATTGAAGGTACAGGACGAACAACAGACGTTCCCATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT209207 WP_000138932.1 NZ_CP078521:c2102042-2101749 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT209207 NZ_CP103964:c2203019-2202747 [Staphylococcus hyicus]
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA
ATGGCAGTTACTTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAATCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGCTATTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|