Detailed information of TA system TA209201

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1884877..1885653
• Replicon: chromosome
• Accession: NZ_CP078521
• Organism: Staphylococcus aureus strain ATCC 29213

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KWH15_RS09100
• Protein ID: WP_000031108.1
• Coordinates: 1884877..1885029 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KWH15_RS09105
• Protein ID: WP_001251224.1
• Coordinates: 1885054..1885653 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KWH15_RS09085 (1881079)	1881079..1881900	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KWH15_RS09090 (1882353)	1882353..1883738	-	1386	WP_000116228.1	class II fumarate hydratase	-
KWH15_RS09095 (1883934)	1883934..1884329	-	396	WP_000901023.1	hypothetical protein	-
KWH15_RS09100 (1884877)	1884877..1885029	-	153	WP_000031108.1	SAS053 family protein	Toxin
KWH15_RS09105 (1885054)	1885054..1885653	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KWH15_RS09110 (1885812)	1885812..1886282	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KWH15_RS09115 (1886287)	1886287..1887414	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
KWH15_RS09120 (1887565)	1887565..1888287	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KWH15_RS09125 (1888280)	1888280..1889737	-	1458	WP_031768944.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T209201 WP_000031108.1 NZ_CP078521:c1885029-1884877 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T209201 NZ_CP103958:c960875-960630 [Brucella sp. 1315]
ATGAAGATCATCTGGGACGAACCGAAGCGACAGACCAACATTGCCAAGCACGGCTTGGACTTCGCTGACCTGCATTTCGA
ATTCTTCCTGTCGGCTAAGGTCTTCCCCACCAAGGCAGATCGCCTGATGGCAATCGGAGAATTCAACGGCCTGATTATCA
TCGCCGTCATTTTCAAGCCGGTTGGTTCGGAAGCCCTCTCCGTGATCTCCATGCGTCCAGCAAGCCAGAAGGAAAGGAAG
CTCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT209201 WP_001251224.1 NZ_CP078521:c1885653-1885054 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT209201 NZ_CP103958:c960630-960316 [Brucella sp. 1315]
ATGGGTATCAAATTTTCCTCTAAGCGCCCTCTCACTCAGGAAGAAGAGGCAGAAATTCAGAAGATGATCGCAAGCGATCC
CGATGCACCGGAAGCCACCGATGAACAGCTTGCCAAGGCCAAGCCTTTCAAGGAAGCCTTTCCAGATATGGCCGCCAAGA
TGGAGAAGGCCATTCGAGGCCGGCCGCGCATCGACAATCCCAAGACGCCGGTTACTATCCGGCTCGATCAGGATGTAGTT
CAACGCTTCAAGGCCACCGGCAAAGGCTGGCAGGGCCGTATGAACGATGCCCTGCGCAAAGCTGTCGGGCTTTGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4