Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 804782..805259 | Replicon | chromosome |
| Accession | NZ_CP078521 | ||
| Organism | Staphylococcus aureus strain ATCC 29213 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | KWH15_RS03795 | Protein ID | WP_000052076.1 |
| Coordinates | 804782..804970 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | KWH15_RS03800 | Protein ID | WP_001059690.1 |
| Coordinates | 804999..805259 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KWH15_RS03765 (800776) | 800776..801297 | + | 522 | WP_000824482.1 | hypothetical protein | - |
| KWH15_RS03770 (801638) | 801638..802324 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
| KWH15_RS03775 (802681) | 802681..802881 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| KWH15_RS03780 (803373) | 803373..803591 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| KWH15_RS03785 (803653) | 803653..803937 | - | 285 | WP_001004399.1 | hypothetical protein | - |
| KWH15_RS03790 (804025) | 804025..804594 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| KWH15_RS03795 (804782) | 804782..804970 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| KWH15_RS03800 (804999) | 804999..805259 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| KWH15_RS03805 (805600) | 805600..805803 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| KWH15_RS03810 (805800) | 805800..806036 | - | 237 | WP_000349581.1 | hypothetical protein | - |
| KWH15_RS03815 (806261) | 806261..806842 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| KWH15_RS03820 (806915) | 806915..807532 | - | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| KWH15_RS03825 (807687) | 807687..808181 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| KWH15_RS03830 (808580) | 808580..809002 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| KWH15_RS03835 (809150) | 809150..809866 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T209198 WP_000052076.1 NZ_CP078521:c804970-804782 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T209198 NZ_CP103902:378904-379323 [Corynebacterium diphtheriae bv. mitis]
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT209198 WP_001059690.1 NZ_CP078521:c805259-804999 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT209198 NZ_CP103902:378293-378859 [Corynebacterium diphtheriae bv. mitis]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |