Detailed information of TA system TA209195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1245520..1246148
• Replicon: chromosome
• Accession: NZ_CP078508
• Organism: Actinobacillus pleuropneumoniae serovar 8 str. 405

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: KV188_RS05945
• Protein ID: WP_005609156.1
• Coordinates: 1245750..1246148 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: KV188_RS05940
• Protein ID: WP_039709385.1
• Coordinates: 1245520..1245750 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KV188_RS05930 (KV188_05930)	1243369..1245000	+	1632	WP_005613299.1	hypothetical protein	-
KV188_RS05935 (KV188_05935)	1245272..1245412	-	141	WP_162835170.1	hypothetical protein	-
KV188_RS05940 (KV188_05940)	1245520..1245750	+	231	WP_039709385.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
KV188_RS05945 (KV188_05945)	1245750..1246148	+	399	WP_005609156.1	tRNA(fMet)-specific endonuclease VapC	Toxin
KV188_RS05950 (KV188_05950)	1246283..1246699	-	417	WP_005609158.1	DUF417 family protein	-
KV188_RS05955 (KV188_05955)	1246946..1247596	+	651	WP_039709386.1	DUF2202 domain-containing protein	-
KV188_RS05960 (KV188_05960)	1247671..1248330	-	660	WP_039709387.1	hypothetical protein	-
KV188_RS05965 (KV188_05965)	1248576..1248737	-	162	WP_160260668.1	hypothetical protein	-
KV188_RS05970 (KV188_05970)	1248730..1249401	-	672	WP_039709388.1	hypothetical protein	-
KV188_RS05975 (KV188_05975)	1249473..1250795	-	1323	WP_039709389.1	HslU--HslV peptidase ATPase subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1230038..1261967	31929

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15066.37 Da
• Isoelectric Point: 7.3824

>T209195 WP_005609156.1 NZ_CP078508:1245750-1246148 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Nucleotide

• Length: 399 bp

>T209195 NZ_CP103899:c377535-377116 [Corynebacterium diphtheriae bv. gravis]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8581.65 Da
• Isoelectric Point: 4.5203

>AT209195 WP_039709385.1 NZ_CP078508:1245520-1245750 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREDL

Nucleotide

• Length: 231 bp

>AT209195 NZ_CP103899:c378146-377580 [Corynebacterium diphtheriae bv. gravis]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG