Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1027946..1028677 | Replicon | chromosome |
| Accession | NZ_CP078508 | ||
| Organism | Actinobacillus pleuropneumoniae serovar 8 str. 405 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | KV188_RS04845 | Protein ID | WP_005598840.1 |
| Coordinates | 1027946..1028413 (-) | Length | 156 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | B0BRD3 |
| Locus tag | KV188_RS04850 | Protein ID | WP_005619269.1 |
| Coordinates | 1028417..1028677 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KV188_RS04820 (KV188_04820) | 1023306..1023677 | - | 372 | WP_005598830.1 | CrcB family protein | - |
| KV188_RS04825 (KV188_04825) | 1023680..1024744 | - | 1065 | WP_039709309.1 | MFS transporter | - |
| KV188_RS04830 (KV188_04830) | 1024839..1025948 | + | 1110 | WP_039709310.1 | anhydro-N-acetylmuramic acid kinase | - |
| KV188_RS04835 (KV188_04835) | 1026001..1026915 | + | 915 | WP_005598836.1 | N-acetylmuramic acid 6-phosphate etherase | - |
| KV188_RS04840 (KV188_04840) | 1026982..1027863 | - | 882 | WP_005598838.1 | 50S ribosomal protein L11 methyltransferase | - |
| KV188_RS04845 (KV188_04845) | 1027946..1028413 | - | 468 | WP_005598840.1 | GNAT family N-acetyltransferase | Toxin |
| KV188_RS04850 (KV188_04850) | 1028417..1028677 | - | 261 | WP_005619269.1 | DUF1778 domain-containing protein | Antitoxin |
| KV188_RS04855 (KV188_04855) | 1028798..1030258 | - | 1461 | WP_039709592.1 | metalloprotease TldD | - |
| KV188_RS04860 (KV188_04860) | 1030388..1031647 | + | 1260 | WP_039709311.1 | tRNA lysidine(34) synthetase TilS | - |
| KV188_RS04865 (KV188_04865) | 1031674..1031964 | - | 291 | WP_005602215.1 | DUF5389 family protein | - |
| KV188_RS04870 (KV188_04870) | 1031966..1032859 | - | 894 | WP_005598850.1 | site-specific tyrosine recombinase XerD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 156 a.a. Molecular weight: 17206.22 Da Isoelectric Point: 8.9312
>T209194 WP_005598840.1 NZ_CP078508:c1028413-1027946 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGIKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL
Download Length: 468 bp
>T209194 NZ_CP103898:c377535-377116 [Corynebacterium diphtheriae bv. gravis]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9796.14 Da Isoelectric Point: 4.4883
>AT209194 WP_005619269.1 NZ_CP078508:c1028677-1028417 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE
Download Length: 261 bp
>AT209194 NZ_CP103898:c378146-377580 [Corynebacterium diphtheriae bv. gravis]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|