Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | toxTA/Tad-couple_hipB |
| Location | 821749..822394 | Replicon | chromosome |
| Accession | NZ_CP078508 | ||
| Organism | Actinobacillus pleuropneumoniae serovar 8 str. 405 | ||
Toxin (Protein)
| Gene name | toxT | Uniprot ID | B0BQU7 |
| Locus tag | KV188_RS03815 | Protein ID | WP_005619674.1 |
| Coordinates | 822023..822394 (-) | Length | 124 a.a. |
Antitoxin (Protein)
| Gene name | toxA | Uniprot ID | - |
| Locus tag | KV188_RS03810 | Protein ID | WP_005598477.1 |
| Coordinates | 821749..822042 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KV188_RS03780 (KV188_03780) | 817081..817764 | - | 684 | WP_005601946.1 | arginine ABC transporter permease ArtM | - |
| KV188_RS03785 (KV188_03785) | 817764..818435 | - | 672 | WP_005601949.1 | arginine ABC transporter permease ArtQ | - |
| KV188_RS03790 (KV188_03790) | 818441..819160 | - | 720 | WP_005619670.1 | transporter substrate-binding domain-containing protein | - |
| KV188_RS03795 (KV188_03795) | 819180..819914 | - | 735 | WP_005598473.1 | arginine ABC transporter ATP-binding protein ArtP | - |
| KV188_RS03800 (KV188_03800) | 820139..820636 | - | 498 | WP_005601953.1 | YbhB/YbcL family Raf kinase inhibitor-like protein | - |
| KV188_RS03805 (KV188_03805) | 820709..821671 | + | 963 | WP_005619672.1 | calcium/sodium antiporter | - |
| KV188_RS03810 (KV188_03810) | 821749..822042 | - | 294 | WP_005598477.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KV188_RS03815 (KV188_03815) | 822023..822394 | - | 372 | WP_005619674.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KV188_RS03820 (KV188_03820) | 822588..824339 | + | 1752 | WP_039709264.1 | protein-disulfide reductase DsbD | - |
| KV188_RS03825 (KV188_03825) | 824397..824966 | + | 570 | WP_005608594.1 | elongation factor P hydroxylase | - |
| KV188_RS03830 (KV188_03830) | 825010..825864 | - | 855 | WP_005598486.1 | 16S rRNA (cytidine(1402)-2'-O)-methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 15066.57 Da Isoelectric Point: 10.4054
>T209193 WP_005619674.1 NZ_CP078508:c822394-822023 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF
Download Length: 372 bp
>T209193 NZ_CP103897:2387949-2388368 [Corynebacterium diphtheriae bv. gravis]
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
ATGGTGAAAAAGTTGGTCTACTTATCCTGCACCTTAAATCAGAAGTGCGGGCAGCGAACAGGTCCCCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGCGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGACG
TCTTGCTGTACCCGACCATATACGACCAAGCGGCCGCGCTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGG
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAGGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10935.81 Da Isoelectric Point: 10.3120
>AT209193 WP_005598477.1 NZ_CP078508:c822042-821749 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR
Download Length: 294 bp
>AT209193 NZ_CP103897:2387338-2387904 [Corynebacterium diphtheriae bv. gravis]
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCTCCATGTTGCAGCGCGTGTACTTGAGCTGCGCCCTTCCTGCGACAAGATGAAGCTGTACAAGCTGTG
TTACTTCTCCCAGGGTTGGCACTTGGCGTGGACAGGTCGTCCGCTGTTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACCTTGCGTCAGGCTAGCGGGCTTCGTGCCGATGATGACCGTCTAGTGACCCAAATTTGGAGCGGGGAC
AGTTCCCAACTCATCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGCGATCTTGAGTCCTTTCACCT
GTCCGATTTGAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCAACCTCCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTGAACGCCTACCT
TCCATGGCACTTGATGCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|