Detailed information of TA system TA209191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 31004..31654
• Replicon: chromosome
• Accession: NZ_CP078508
• Organism: Actinobacillus pleuropneumoniae serovar 8 str. 405

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B0BNU3
• Locus tag: KV188_RS00205
• Protein ID: WP_005614926.1
• Coordinates: 31004..31393 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BNU4
• Locus tag: KV188_RS00210
• Protein ID: WP_005604117.1
• Coordinates: 31394..31654 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KV188_RS00190 (KV188_00190)	26580..27770	+	1191	WP_171823688.1	amino acid aminotransferase	-
KV188_RS00195 (KV188_00195)	27950..29236	-	1287	WP_009874699.1	Xaa-Pro aminopeptidase	-
KV188_RS00200 (KV188_00200)	29645..30868	-	1224	WP_039709068.1	ATP-binding protein	-
KV188_RS00205 (KV188_00205)	31004..31393	-	390	WP_005614926.1	type II toxin-antitoxin system VapC family toxin	Toxin
KV188_RS00210 (KV188_00210)	31394..31654	-	261	WP_005604117.1	hypothetical protein	Antitoxin
KV188_RS00215 (KV188_00215)	31788..33809	-	2022	WP_058230468.1	excinuclease ABC subunit UvrB	-
KV188_RS00220 (KV188_00220)	33986..34798	+	813	WP_039709069.1	iron uptake system protein EfeO	-
KV188_RS00225 (KV188_00225)	34810..36003	+	1194	WP_005604123.1	iron uptake transporter deferrochelatase/peroxidase subunit	-
KV188_RS00230 (KV188_00230)	36014..36634	+	621	WP_039709071.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14837.17 Da
• Isoelectric Point: 5.1295

>T209191 WP_005614926.1 NZ_CP078508:c31393-31004 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK

Nucleotide

• Length: 390 bp

>T209191 NZ_CP103895:c995440-995177 [Corynebacterium diphtheriae bv. mitis]
GTGGCTTGGGAGATTAGTTTTTCTCCTCGGGCGGTGAAGTCGTTTAAGAAGCTCGATACGGGTGAGCAGCGGAGGGTGAG
TAAGTTTCTGCGGGAGGTTGGCGCCCTTGAGGACCCGAGGTTACGAGGTAAGGCATTAACAGCCAATAAGTCGGGTTTGT
GGCGCTGGCGTGTGGGGGACTATCGGATTATTGCTGACATTGTGGACGCGCGTGTTGTCGTCGTTGTGGTTGACGTTGGG
CACCGCTCGAAGGTCTACGACTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10289.63 Da
• Isoelectric Point: 5.1867

>AT209191 WP_005604117.1 NZ_CP078508:c31654-31394 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT209191 NZ_CP103895:c995660-995424 [Corynebacterium diphtheriae bv. mitis]
ATGAGTGGTTCGGTGATTAGCTTGCGTATCGATGACGAGCAGAAGCGGCGTTTGGATGAGCTGTCGCGACGTACGGGGCG
GCCGTGTTCGTTTTATCTTCGGGAAGCGTTGAGTGCACATCTGGCTGATCTGGAGTATGTGTATCGCTTGGAGGAGGAGG
CTGCTCAGGTTCGTCGTGGGGAGTTGGGAACTGTGCCGTTGAGTCAGCTGGAGCGCGAGTGTGGCTTGGGAGATTAG

Structures

Toxin

• AlphaFold DB: A3N029

Antitoxin

• AlphaFold DB: A3N030