Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta-epsilon |
Location | 5936..7073 | Replicon | plasmid pNS2A |
Accession | NZ_CP078163 | ||
Organism | Enterococcus faecalis strain NS2 |
Toxin (Protein)
Gene name | zeta | Uniprot ID | P0A4M2 |
Locus tag | KVY10_RS12555 | Protein ID | WP_002332783.1 |
Coordinates | 5936..6799 (-) | Length | 288 a.a. |
Antitoxin (Protein)
Gene name | epsilon | Uniprot ID | Q9AL19 |
Locus tag | KVY10_RS12560 | Protein ID | WP_002326825.1 |
Coordinates | 6801..7073 (-) | Length | 91 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KVY10_RS12520 (KVY10_12520) | 1033..1116 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
KVY10_RS12525 (KVY10_12525) | 1658..2451 | - | 794 | Protein_3 | aminoglycoside O-phosphotransferase APH(3')-IIIa | - |
KVY10_RS12530 (KVY10_12530) | 2544..3086 | - | 543 | WP_000627290.1 | streptothricin N-acetyltransferase Sat4 | - |
KVY10_RS12535 (KVY10_12535) | 3083..3589 | - | 507 | Protein_5 | aminoglycoside 6-adenylyltransferase | - |
KVY10_RS12540 (KVY10_12540) | 3664..4344 | + | 681 | WP_010710189.1 | IS6-like element IS1216 family transposase | - |
KVY10_RS12545 (KVY10_12545) | 4378..4884 | - | 507 | WP_002415429.1 | trimethoprim-resistant dihydrofolate reductase DfrG | - |
KVY10_RS12550 (KVY10_12550) | 5180..5497 | - | 318 | WP_002326830.1 | hypothetical protein | - |
KVY10_RS12555 (KVY10_12555) | 5936..6799 | - | 864 | WP_002332783.1 | zeta toxin family protein | Toxin |
KVY10_RS12560 (KVY10_12560) | 6801..7073 | - | 273 | WP_002326825.1 | antitoxin | Antitoxin |
KVY10_RS12565 (KVY10_12565) | 7091..7306 | - | 216 | WP_001835296.1 | peptide-binding protein | - |
KVY10_RS12570 (KVY10_12570) | 7398..8294 | - | 897 | WP_002326827.1 | ParA family protein | - |
KVY10_RS12575 (KVY10_12575) | 8397..8657 | - | 261 | Protein_13 | topoisomerase DNA-binding C4 zinc finger domain-containing protein | - |
KVY10_RS12580 (KVY10_12580) | 8827..9564 | - | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
KVY10_RS12585 (KVY10_12585) | 9689..9772 | - | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
KVY10_RS12590 (KVY10_12590) | 10204..10575 | - | 372 | WP_002358205.1 | hypothetical protein | - |
KVY10_RS12595 (KVY10_12595) | 10568..11413 | - | 846 | WP_000239313.1 | AAA family ATPase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | IS/Tn | erm(B) / aph(3')-III / dfrG | - | 171..9564 | 9393 | |
- | inside | Conjugative plasmid | erm(B) / aph(3')-III / dfrG / cat / tet(L) / tet(M) / fexA / optrA | - | 1..77697 | 77697 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 288 a.a. Molecular weight: 32675.27 Da Isoelectric Point: 7.3939
>T209188 WP_002332783.1 NZ_CP078163:c6799-5936 [Enterococcus faecalis]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKYVTPYSNRMTEAIISRLRDKGYNLVIEGTGRTTDVPIQTATMLQAKDYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLLGGQPGSGKTSLRSAISEETQGNVVIIDNDTFKQQHPNFDELV
KLYEKDVVKYVTPYSNRMTEAIISRLRDKGYNLVIEGTGRTTDVPIQTATMLQAKDYETKMYVMAVPKINSYLGTIERYE
TMYADDPMTARATPKQAHDIVVKNLPTNLETLHKTGLFSDIRLYNREGVKLYSSLETPSISPKETLERELNRKVSGKEIQ
PTLERIEQKMVQNQHQETPEFKAIQQKMESLQPPTPPIPKTPKLPGI
Download Length: 864 bp
>T209188 NZ_CP103894:378918-379337 [Corynebacterium diphtheriae bv. mitis]
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
ATGGTGAACAAGTTGGTCTACTTATCCTGCACCTTAAATCAGGAGTGCGGGAAGCGAACAGGTCCTCACAGAGAACCTGA
ACCTTTTCTTGGATTCTCCGTGAGGGATCGGAGTGGGCTAGAGGGCGCGATCGCTTCAGTATTTCAATCGTCGTTTGGCG
TCTTGCTGTACCCGACCATCTACGACCAAGCGGCCGCACTCCTGTTCAAGCTGGCAAACGGGCATTACTTCCAAGACGGA
AACAAGCGAACAGCATTCCACCTGTGCTTAGCCTACCTACGGGCCAATAACGTTCACGTCAGTCCCCCTCGGTCTGATGA
CGTCATCACTTTACTTCAGACCACGGTGAGTCGCTCAGGAAGCCAAGAAAACGGGATAGCGTTCGTTAGACAAAAGCTTT
TGGACTGGACCGTAGACTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10720.17 Da Isoelectric Point: 4.4865
>AT209188 WP_002326825.1 NZ_CP078163:c7073-6801 [Enterococcus faecalis]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA
Download Length: 273 bp
>AT209188 NZ_CP103894:378307-378873 [Corynebacterium diphtheriae bv. mitis]
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
ATGATCAGCATCCACGATGTTGCAGCGCGTGTACTTGAGCTGCACCCTTCCTGCGACAAGATGAAGCTGTACAAACTGTG
TTACTTCTCCCAGGGGTGGCACTTGGCATGGACAGGTCGTCCACTATTCAACGAAGAGCTACAGGCGTGGAAGTACGGGG
CCGTATCTCCTACTTTGCGTCAGGCTAGCGAGCTTCGTGCCGATGATGACCGTCGAGTGACCCAAATTTGGAGCGGGGAC
AGTTCTCAACTCACCGATTACGAGCGGTCAGTCGTGGACACTGTTGTTTCGTTCTATGGAGATCTTGGGTCTTTTCACCT
GTCCGATTTAAGCCACGGCTTCGCCTGGTCCACCGTACGAGGCGACCTTCCTCCAGACGCCTCGTGCAGCGATGTGATCC
CTCACTCTCTGATCCGTCGTGAGTTTGTCGAGAATGCTTGGGGCGAAGCTCCTACGCCAAACGCTCCTTCACACCTGCCT
TCCATGGCACTTGATTCTCTCGAGCAGGCAGCCGATGACGTTGCTGCCGAAAATGCAGAGACGCTTCGACTTCTCGCTTT
CATCTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | P0A4M2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M2AF93 |