Detailed information of TA system TA209150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1984314..1984782
• Replicon: chromosome
• Accession: NZ_CP078159
• Organism: Staphylococcus haemolyticus strain NY5

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: Q4L4Q4
• Locus tag: KVY09_RS09950
• Protein ID: WP_011276326.1
• Coordinates: 1984594..1984782 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: KVY09_RS13075
• Protein ID: WP_070441716.1
• Coordinates: 1984314..1984571 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY09_RS09915 (KVY09_09915)	1979516..1980241	-	726	WP_070441705.1	type I 3-dehydroquinate dehydratase	-
KVY09_RS09920 (KVY09_09920)	1980404..1980826	+	423	WP_016931015.1	organic hydroperoxide resistance protein	-
KVY09_RS09925 (KVY09_09925)	1981102..1981593	+	492	WP_070441707.1	GNAT family N-acetyltransferase	-
KVY09_RS09930 (KVY09_09930)	1981724..1982340	+	617	Protein_1939	LysE family transporter	-
KVY09_RS09935 (KVY09_09935)	1982490..1983098	-	609	WP_070441710.1	histidine phosphatase family protein	-
KVY09_RS09940 (KVY09_09940)	1983326..1983568	+	243	WP_011276324.1	hypothetical protein	-
KVY09_RS09945 (KVY09_09945)	1983560..1983763	-	204	WP_070441713.1	sterile alpha motif-like domain-containing protein	-
KVY09_RS13075	1984314..1984571	+	258	WP_070441716.1	hypothetical protein	Antitoxin
KVY09_RS09950 (KVY09_09950)	1984594..1984782	+	189	WP_011276326.1	hypothetical protein	Toxin
KVY09_RS09955 (KVY09_09955)	1984900..1985481	+	582	WP_070441719.1	lipoprotein N-acylation protein LnsA	-
KVY09_RS09960 (KVY09_09960)	1985529..1985765	-	237	WP_016931008.1	hypothetical protein	-
KVY09_RS09965 (KVY09_09965)	1985927..1986676	+	750	WP_256262276.1	hypothetical protein	-
KVY09_RS09970 (KVY09_09970)	1986746..1987354	-	609	WP_070441725.1	GNAT family N-acetyltransferase	-
KVY09_RS09975 (KVY09_09975)	1987491..1988237	+	747	WP_016931005.1	poly-gamma-glutamate hydrolase family protein	-
KVY09_RS09980 (KVY09_09980)	1988313..1988600	+	288	WP_016931004.1	hypothetical protein	-
KVY09_RS09985 (KVY09_09985)	1988840..1989064	+	225	WP_053026364.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-80)

Antitoxin

• Uncharacterised protein family HicB (60-112)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7110.80 Da
• Isoelectric Point: 9.6269

>T209150 WP_011276326.1 NZ_CP078159:1984594-1984782 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Nucleotide

• Length: 189 bp

>T209150 NZ_CP103864:c1672509-1672234 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGC
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9850.85 Da
• Isoelectric Point: 4.0625

>AT209150 WP_070441716.1 NZ_CP078159:1984314-1984571 [Staphylococcus haemolyticus]
MNNNKIFWINIFITLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIAMLLYYIYPI
VYTFF

Nucleotide

• Length: 258 bp

>AT209150 NZ_CP103864:c1672237-1671878 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A0A2A1KAB5