Detailed information of TA system TA209149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 990109..990880
• Replicon: chromosome
• Accession: NZ_CP078159
• Organism: Staphylococcus haemolyticus strain NY5

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: KVY09_RS05005
• Protein ID: WP_141738627.1
• Coordinates: 990731..990880 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: KVY09_RS05000
• Protein ID: WP_053025425.1
• Coordinates: 990109..990708 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY09_RS04980 (KVY09_04980)	985994..987446	+	1453	Protein_958	ABC transporter substrate-binding protein/permease	-
KVY09_RS04985 (KVY09_04985)	987439..988161	+	723	WP_070441476.1	amino acid ABC transporter ATP-binding protein	-
KVY09_RS04990 (KVY09_04990)	988339..989466	+	1128	WP_218449345.1	tRNA epoxyqueuosine(34) reductase QueG	-
KVY09_RS04995 (KVY09_04995)	989467..989937	+	471	WP_053025428.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KVY09_RS05000 (KVY09_05000)	990109..990708	+	600	WP_053025425.1	glucosamine-6-phosphate isomerase	Antitoxin
KVY09_RS05005 (KVY09_05005)	990731..990880	+	150	WP_141738627.1	SAS053 family protein	Toxin
KVY09_RS05010 (KVY09_05010)	991091..991486	+	396	WP_053025423.1	hypothetical protein	-
KVY09_RS05015 (KVY09_05015)	991692..993077	+	1386	WP_070441473.1	class II fumarate hydratase	-
KVY09_RS05020 (KVY09_05020)	993143..993967	-	825	WP_070441470.1	RluA family pseudouridine synthase	-
KVY09_RS05025 (KVY09_05025)	994155..995264	+	1110	WP_070441467.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5824.20 Da
• Isoelectric Point: 3.9484

>T209149 WP_141738627.1 NZ_CP078159:990731-990880 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDRLNQSHE

Nucleotide

• Length: 150 bp

>T209149 NZ_CP103864:c1629805-1629278 [Escherichia coli O157:H7]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATAAATCGCTGGGCTTTATCCCTTTAGTCGGGGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATTGAACTGCTTTTTACACAGAGCGATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22286.14 Da
• Isoelectric Point: 4.7588

>AT209149 WP_053025425.1 NZ_CP078159:990109-990708 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PTSQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPADLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT209149 NZ_CP103864:c1630078-1629812 [Escherichia coli O157:H7]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA