Detailed information of TA system TA209147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 828078..828589
• Replicon: chromosome
• Accession: NZ_CP078159
• Organism: Staphylococcus haemolyticus strain NY5

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: KVY09_RS04030
• Protein ID: WP_011275259.1
• Coordinates: 828383..828589 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: KVY09_RS04025
• Protein ID: WP_136719879.1
• Coordinates: 828078..828371 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KVY09_RS04005 (KVY09_04005)	823231..824106	+	876	WP_037551964.1	membrane protein insertase YidC	-
KVY09_RS04010 (KVY09_04010)	824305..825621	+	1317	WP_011274424.1	ISL3-like element ISSha1 family transposase	-
KVY09_RS04015 (KVY09_04015)	825666..826307	-	642	WP_070440772.1	HD domain-containing protein	-
KVY09_RS04020 (KVY09_04020)	826407..827891	-	1485	WP_070440775.1	cardiolipin synthase	-
KVY09_RS04025 (KVY09_04025)	828078..828371	+	294	WP_136719879.1	copper-sensing transcriptional repressor CsoR	Antitoxin
KVY09_RS04030 (KVY09_04030)	828383..828589	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
KVY09_RS04035 (KVY09_04035)	828697..828834	+	138	WP_141738622.1	Lmo0850 family protein	-
KVY09_RS04040 (KVY09_04040)	828883..830073	-	1191	WP_070440778.1	FtsW/RodA/SpoVE family cell cycle protein	-
KVY09_RS04045 (KVY09_04045)	830491..831561	+	1071	WP_053020221.1	D-alanine--D-alanine ligase	-
KVY09_RS04050 (KVY09_04050)	831577..832932	+	1356	WP_070440781.1	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	824305..825621	1316

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (15-92)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T209147 WP_011275259.1 NZ_CP078159:828383-828589 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T209147 NZ_CP103864:1329001-1329465 [Escherichia coli O157:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11235.91 Da
• Isoelectric Point: 7.3854

>AT209147 WP_136719879.1 NZ_CP078159:828078-828371 [Staphylococcus haemolyticus]
MNNHENAHHSKQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT209147 NZ_CP103864:1328666-1329001 [Escherichia coli O157:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAGCAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATACAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8