209143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 88589..89111 Replicon plasmid pJNQH579-1
Accession NZ_CP078147
Organism Klebsiella variicola strain JNQH579

Toxin (Protein)


Gene name stbE Uniprot ID -
Locus tag KW408_RS27450 Protein ID WP_218408497.1
Coordinates 88589..88873 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag KW408_RS27455 Protein ID WP_004187025.1
Coordinates 88863..89111 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW408_RS27420 (KW408_27420) 84467..84721 + 255 WP_023328991.1 Hha/YmoA family nucleoid-associated regulatory protein -
KW408_RS27425 (KW408_27425) 84807..85151 + 345 WP_023328992.1 hypothetical protein -
KW408_RS27430 (KW408_27430) 85288..86319 - 1032 WP_049084079.1 IS630-like element ISEc33 family transposase -
KW408_RS27435 (KW408_27435) 86484..86855 - 372 Protein_87 GntR family transcriptional regulator -
KW408_RS27445 (KW408_27445) 88190..88573 + 384 Protein_89 transposase -
KW408_RS27450 (KW408_27450) 88589..88873 - 285 WP_218408497.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KW408_RS27455 (KW408_27455) 88863..89111 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
KW408_RS27460 (KW408_27460) 89620..90588 - 969 WP_218408498.1 IS5 family transposase -
KW408_RS27465 (KW408_27465) 90764..91708 - 945 WP_218408499.1 ornithine cyclodeaminase family protein -
KW408_RS27470 (KW408_27470) 91705..92724 - 1020 WP_218408500.1 pyridoxal-phosphate dependent enzyme -
KW408_RS27475 (KW408_27475) 92820..93545 - 726 WP_218408505.1 amino acid ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..197434 197434
- inside IScluster/Tn - - 85288..90588 5300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T209143 WP_218408497.1 NZ_CP078147:c88873-88589 [Klebsiella variicola]
MTYKLAFNESALKEWKKLGHTIQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

>T209143 NZ_CP103863:1662271-1662387 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT209143 WP_004187025.1 NZ_CP078147:c89111-88863 [Klebsiella variicola]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp

>AT209143 NZ_CP103863:c1662503-1662298 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References