Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4590265..4590922 Replicon chromosome
Accession NZ_CP078146
Organism Klebsiella variicola strain JNQH579

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KW408_RS22080 Protein ID WP_002916310.1
Coordinates 4590265..4590675 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KW408_RS22085 Protein ID WP_002916312.1
Coordinates 4590656..4590922 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW408_RS22060 (KW408_22060) 4586265..4587998 - 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -
KW408_RS22065 (KW408_22065) 4588004..4588717 - 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KW408_RS22070 (KW408_22070) 4588740..4589636 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
KW408_RS22075 (KW408_22075) 4589737..4590258 + 522 WP_008806427.1 flavodoxin FldB -
KW408_RS22080 (KW408_22080) 4590265..4590675 - 411 WP_002916310.1 protein YgfX Toxin
KW408_RS22085 (KW408_22085) 4590656..4590922 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KW408_RS22090 (KW408_22090) 4591168..4592151 + 984 WP_008806428.1 tRNA-modifying protein YgfZ -
KW408_RS22095 (KW408_22095) 4592619..4593278 - 660 WP_008806429.1 hemolysin III family protein -
KW408_RS22100 (KW408_22100) 4593442..4593753 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
KW408_RS22105 (KW408_22105) 4593804..4594532 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T209139 WP_002916310.1 NZ_CP078146:c4590675-4590265 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T209139 NZ_CP103863:c1038052-1037711 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCAAGGACAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT209139 WP_002916312.1 NZ_CP078146:c4590922-4590656 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT209139 NZ_CP103863:c1038282-1038052 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References