Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1126893..1127512 Replicon chromosome
Accession NZ_CP078146
Organism Klebsiella variicola strain JNQH579

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KW408_RS05380 Protein ID WP_002892050.1
Coordinates 1126893..1127111 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1F2MBN7
Locus tag KW408_RS05385 Protein ID WP_008805436.1
Coordinates 1127138..1127512 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KW408_RS05345 (KW408_05345) 1122936..1123199 + 264 WP_008805431.1 type B 50S ribosomal protein L31 -
KW408_RS05350 (KW408_05350) 1123199..1123339 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KW408_RS05355 (KW408_05355) 1123336..1124034 - 699 WP_211744154.1 GNAT family protein -
KW408_RS05360 (KW408_05360) 1124135..1125592 + 1458 WP_211744153.1 PLP-dependent aminotransferase family protein -
KW408_RS05365 (KW408_05365) 1125561..1126031 - 471 WP_008805434.1 YlaC family protein -
KW408_RS05370 (KW408_05370) 1126068..1126196 + 129 Protein_1031 hypothetical protein -
KW408_RS05375 (KW408_05375) 1126168..1126734 - 567 WP_008805435.1 maltose O-acetyltransferase -
KW408_RS05380 (KW408_05380) 1126893..1127111 - 219 WP_002892050.1 HHA domain-containing protein Toxin
KW408_RS05385 (KW408_05385) 1127138..1127512 - 375 WP_008805436.1 Hha toxicity modulator TomB Antitoxin
KW408_RS05390 (KW408_05390) 1127995..1131141 - 3147 WP_008805437.1 multidrug efflux RND transporter permease subunit AcrB -
KW408_RS05395 (KW408_05395) 1131164..1132357 - 1194 WP_008805438.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T209127 WP_002892050.1 NZ_CP078146:c1127111-1126893 [Klebsiella variicola]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T209127 NZ_CP103860:512744-513010 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14384.06 Da        Isoelectric Point: 4.8989

>AT209127 WP_008805436.1 NZ_CP078146:c1127512-1127138 [Klebsiella variicola]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYTEDNKLVAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT209127 NZ_CP103860:512493-512744 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MBN7

References