Detailed information of TA system TA209126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 245893..247574
• Replicon: chromosome
• Accession: NZ_CP078146
• Organism: Klebsiella variicola strain JNQH579

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: KW408_RS01145
• Protein ID: WP_022065798.1
• Coordinates: 246657..247574 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: KW408_RS01140
• Protein ID: WP_008807257.1
• Coordinates: 245893..246651 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KW408_RS01125 (KW408_01125)	241445..242131	-	687	WP_008807260.1	tetratricopeptide repeat protein	-
KW408_RS01130 (KW408_01130)	242660..244807	-	2148	WP_077625434.1	formate dehydrogenase subunit alpha	-
KW408_RS01135 (KW408_01135)	245080..245808	+	729	WP_008807258.1	response regulator transcription factor	-
KW408_RS01140 (KW408_01140)	245893..246651	+	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
KW408_RS01145 (KW408_01145)	246657..247574	+	918	WP_022065798.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
KW408_RS01150 (KW408_01150)	247699..248706	-	1008	WP_218408273.1	carbohydrate kinase family protein	-
KW408_RS01155 (KW408_01155)	248781..249722	-	942	WP_012543155.1	ABC transporter substrate-binding protein	-
KW408_RS01160 (KW408_01160)	249753..250751	-	999	WP_004206363.1	ribose ABC transporter permease	-
KW408_RS01165 (KW408_01165)	250748..252268	-	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34751.14 Da
• Isoelectric Point: 5.4707

>T209126 WP_022065798.1 NZ_CP078146:246657-247574 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T209126 NZ_CP103860:487478-487585 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT209126 WP_008807257.1 NZ_CP078146:245893-246651 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT209126 NZ_CP103860:c487662-487602 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin

• AlphaFold DB: A0A0B7GCX3