Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4716969..4717585 Replicon chromosome
Accession NZ_CP078142
Organism Salmonella enterica subsp. diarizonae strain LHICA_D1

Toxin (Protein)


Gene name vapC Uniprot ID A0A8E9YCX3
Locus tag JMJ85_RS22585 Protein ID WP_023249114.1
Coordinates 4716969..4717343 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8E9YHE9
Locus tag JMJ85_RS22590 Protein ID WP_001523745.1
Coordinates 4717343..4717585 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ85_RS22570 (4714471) 4714471..4715373 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
JMJ85_RS22575 (4715370) 4715370..4716005 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
JMJ85_RS22580 (4716002) 4716002..4716931 + 930 WP_053509958.1 formate dehydrogenase accessory protein FdhE -
JMJ85_RS22585 (4716969) 4716969..4717343 - 375 WP_023249114.1 type II toxin-antitoxin system VapC family toxin Toxin
JMJ85_RS22590 (4717343) 4717343..4717585 - 243 WP_001523745.1 CopG family transcriptional regulator Antitoxin
JMJ85_RS22595 (4717790) 4717790..4718716 + 927 Protein_4450 alpha/beta hydrolase -
JMJ85_RS22600 (4718802) 4718802..4719113 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
JMJ85_RS22605 (4719110) 4719110..4719556 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
JMJ85_RS22610 (4719571) 4719571..4720512 - 942 WP_024134888.1 fatty acid biosynthesis protein FabY -
JMJ85_RS22615 (4720557) 4720557..4720994 - 438 WP_023249111.1 D-aminoacyl-tRNA deacylase -
JMJ85_RS22620 (4720991) 4720991..4721863 - 873 WP_023249110.1 virulence factor BrkB family protein -
JMJ85_RS22625 (4721857) 4721857..4722456 - 600 WP_000965699.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13836.12 Da        Isoelectric Point: 8.0689

>T209118 WP_023249114.1 NZ_CP078142:c4717343-4716969 [Salmonella enterica subsp. diarizonae]
MVKGSALFDTNILIDLFSGRIEAKHALEAYPPQNAISLITWMEVMVGAKKYHQENRTRIALSAFNVIGVTQEIAERSVIV
RQEYGMKLPDAIILATAQVHRCELVTRNTKDFAGIPGVITPYHL

Download         Length: 375 bp

>T209118 NZ_CP103852:c1200957-1200682 [Ralstonia pseudosolanacearum]
ATGGAGGTCAAGTGGACTGGCAAAGCGGTATCGGACATCACGCGCCTGTACGAATTTCTCTCGCAGGTCAATAAGCCTGC
GGCTATCCGCGTAGTGCAGTCTCTGACTGGCGCACCGAAATCGTTGGTGGTGAACCCGCGTATTGGTGAGCAGTTAGATG
AGTTTGAGCCGCGTGAGGTTCGTCGCATCATCGTGGGTCAGTACGAGATGCGGTATGCGATTCGTGGTTCGGTCATTTAC
GTGCTGCGTTTGTGGCACACGCGCGAGGATCGCTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 4.4463

>AT209118 WP_001523745.1 NZ_CP078142:c4717585-4717343 [Salmonella enterica subsp. diarizonae]
MMAGMDMGRILLDLSDDVIKRLDDLKVQRNLPRAELLREAVEQYLERQDRAETTISKALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp

>AT209118 NZ_CP103852:c1201226-1200957 [Ralstonia pseudosolanacearum]
ATGGCTCATCTTGACACCCGCGTGCTTACCGCCCATGTGCCGGTACAGTTGGCGGAACGAGTCGATCAGATTGCGGAGCG
CCTTGAGCGGTCACGTGGTTGGATCATGAAACAAGCACTCTCTGCCTGGATCGATCAGGAAGAAGAGCGTAGCCGGTTGA
CGCGTGAGGCATTGGCCGATGTGGACGCAGGCACGGTGATCGACCATCAGGCCGTGCAAGCGTGGGCGGATAGCCTTTCG
ACAAGCAAACCGAAAAAGGCGCCGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References