Detailed information of TA system TA209117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4293124..4293640
• Replicon: chromosome
• Accession: NZ_CP078142
• Organism: Salmonella enterica subsp. diarizonae strain LHICA_D1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A735RF37
• Locus tag: JMJ85_RS20730
• Protein ID: WP_063390028.1
• Coordinates: 4293124..4293408 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V1HDU1
• Locus tag: JMJ85_RS20735
• Protein ID: WP_023182636.1
• Coordinates: 4293398..4293640 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ85_RS20715 (4288265)	4288265..4289917	+	1653	WP_053507662.1	alpha,alpha-phosphotrehalase	-
JMJ85_RS20720 (4290327)	4290327..4292465	+	2139	WP_053507663.1	anaerobic ribonucleoside-triphosphate reductase	-
JMJ85_RS20725 (4292650)	4292650..4293114	+	465	WP_023248625.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
JMJ85_RS20730 (4293124)	4293124..4293408	-	285	WP_063390028.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JMJ85_RS20735 (4293398)	4293398..4293640	-	243	WP_023182636.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
JMJ85_RS20740 (4293719)	4293719..4295632	-	1914	WP_218505811.1	BglG family transcription antiterminator	-
JMJ85_RS20745 (4295649)	4295649..4296389	-	741	WP_023248627.1	KDGP aldolase family protein	-
JMJ85_RS20750 (4296386)	4296386..4297504	-	1119	WP_218505813.1	DgaE family pyridoxal phosphate-dependent ammonia lyase	-
JMJ85_RS20755 (4297488)	4297488..4298621	-	1134	WP_218505815.1	amidohydrolase/deacetylase family metallohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11097.07 Da
• Isoelectric Point: 10.3015

>T209117 WP_063390028.1 NZ_CP078142:c4293408-4293124 [Salmonella enterica subsp. diarizonae]
MTYELEFDPRALKEWQKLGETVKKQFRKKLVDVLSNPRVESARLRELPDCYKIKLKISGYRLVYQVQDDVVLVVVIAIGK
REKSAVYRQADKRL

Nucleotide

• Length: 285 bp

>T209117 NZ_CP103852:444932-445345 [Ralstonia pseudosolanacearum]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACGCCGCCAAGGCCGATACGGC
GGAAACGCTGCTGATGACAGGCGGTGTCGTCAGCGTACAGGTGCTGAACGAAACGACGCACGTGATGCGCCGCAAGCTCG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAAGCCGTGCGTGCGCAATGCCGGATCGAGCCGCTGACGCTCGAAACC
CATGAGCTCGGACGGCGTCTCGCAGAACGCTACGGACTGTCGGTCTATGACGCACTGATCGTCGCGGCCGCATTGCTTGC
CGGCTGCAACGTGCTGTATTCCGAGGACATGCAGCACGGCCTGGTGGTCGAGCAGCATCTGCGCATCGTCAATCCTTTTT
CGGCACGGGCATGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9013.38 Da
• Isoelectric Point: 5.0651

>AT209117 WP_023182636.1 NZ_CP078142:c4293640-4293398 [Salmonella enterica subsp. diarizonae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTVTISDSEDALLQTVRERLANPQKGIRVSLDDL

Nucleotide

• Length: 243 bp

>AT209117 NZ_CP103852:444712-444945 [Ralstonia pseudosolanacearum]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCCATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAACTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGTTCCGCGCGCGAGCTGTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Structures

Toxin

• AlphaFold DB: A0A735RF37