Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3583144..3583764 Replicon chromosome
Accession NZ_CP078142
Organism Salmonella enterica subsp. diarizonae strain LHICA_D1

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag JMJ85_RS17195 Protein ID WP_001280991.1
Coordinates 3583546..3583764 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag JMJ85_RS17190 Protein ID WP_000344807.1
Coordinates 3583144..3583518 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMJ85_RS17180 (3578281) 3578281..3579474 + 1194 WP_023246703.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
JMJ85_RS17185 (3579497) 3579497..3582646 + 3150 WP_023246702.1 efflux RND transporter permease AcrB -
JMJ85_RS17190 (3583144) 3583144..3583518 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
JMJ85_RS17195 (3583546) 3583546..3583764 + 219 WP_001280991.1 HHA domain-containing protein Toxin
JMJ85_RS17200 (3583944) 3583944..3584495 + 552 WP_053508533.1 maltose O-acetyltransferase -
JMJ85_RS17205 (3584612) 3584612..3585082 + 471 WP_023246700.1 YlaC family protein -
JMJ85_RS17210 (3585137) 3585137..3585277 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
JMJ85_RS17215 (3585283) 3585283..3585543 - 261 WP_023182818.1 type B 50S ribosomal protein L31 -
JMJ85_RS17220 (3585768) 3585768..3587318 + 1551 WP_218505168.1 EAL domain-containing protein -
JMJ85_RS17230 (3587549) 3587549..3587938 + 390 WP_023246698.1 MGMT family protein -
JMJ85_RS17235 (3587971) 3587971..3588540 - 570 WP_000779808.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T209116 WP_001280991.1 NZ_CP078142:3583546-3583764 [Salmonella enterica subsp. diarizonae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T209116 NZ_CP103852:c271039-270788 [Ralstonia pseudosolanacearum]
ATGCAAAGCTGGCAGTTGCAAGCCGCCAAGGCGCGGTTTTCCGACGTCGTGAAGCGCGCTGCGGATGATGGTCCGCAGGA
AATCACGGTGCATGGCCGCCCGGTTGCGGTTGTGATCTCACGCGCACTGTTCGATCGCTTGAGTGGCAGCGGGGAGTCGC
TGGTCGACTTCATGCGCCAGTCTCCGTTGGCTGGCCTGGACGATGTCGTCTTCGAGCGCGAACGCAGCCTGCCGCGCGAG
GTCGACTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT209116 WP_000344807.1 NZ_CP078142:3583144-3583518 [Salmonella enterica subsp. diarizonae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT209116 NZ_CP103852:c270791-270378 [Ralstonia pseudosolanacearum]
TTGAGCTACCTGATCGACACCAATGTGCTGTCCGAGCTACGCCGCAAGCAGCCCGATGCGCGCGTGCTCGCCTGGATGCA
GGACCGGCCGCGCCAGTCGCTCTACCTGAGCGTGCTGACCCTGGGCGAAATCCGCAAAGGCATCGAGCGGCTGGATGACG
CGGTACGCCGCCAGCACCTGATCGACTGGCTCGAAACGGAACTGCCGAACTACTTCCTCGGCCGCTTGCTCGACGTCGAT
GCGCATACCGCCGACCGCTGGGGCCGGCTGATGTCGAGCGCCAACCGGCCGCTGCCGGCCATCGATGGCCTGCTCGCCGC
CACCGCCCTGCAGCACGACCTCATACTGGTCACGCGCAACACGAAGGATTTCGTCGGGCTCGATGTCCCGCTCATCAACC
CCTGGGAGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References