Detailed information of TA system TA209107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemIK/PRK09812-MazE
• Location: 1940748..1941338
• Replicon: chromosome
• Accession: NZ_CP078142
• Organism: Salmonella enterica subsp. diarizonae strain LHICA_D1

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: -
• Locus tag: JMJ85_RS09375
• Protein ID: WP_098142490.1
• Coordinates: 1941006..1941338 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: pemI
• Uniprot ID: -
• Locus tag: JMJ85_RS09370
• Protein ID: WP_218506365.1
• Coordinates: 1940748..1941005 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ85_RS09355 (1938069)	1938069..1939331	-	1263	WP_218506363.1	hypothetical protein	-
JMJ85_RS09360 (1939731)	1939731..1940198	+	468	WP_218506364.1	hypothetical protein	-
JMJ85_RS09365 (1940195)	1940195..1940400	+	206	Protein_1846	helix-turn-helix domain-containing protein	-
JMJ85_RS09370 (1940748)	1940748..1941005	+	258	WP_218506365.1	antitoxin	Antitoxin
JMJ85_RS09375 (1941006)	1941006..1941338	+	333	WP_098142490.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
JMJ85_RS09380 (1942099)	1942099..1942896	+	798	WP_218506366.1	integrase domain-containing protein	-
JMJ85_RS09385 (1943469)	1943469..1944731	-	1263	WP_218506367.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (1-109)

Antitoxin

• Antitoxin PemI-like (4-84)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 11751.60 Da
• Isoelectric Point: 10.5834

>T209107 WP_098142490.1 NZ_CP078142:1941006-1941338 [Salmonella enterica subsp. diarizonae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARAAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Nucleotide

• Length: 333 bp

>T209107 NZ_CP103850:c2176258-2176049 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGAGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9331.75 Da
• Isoelectric Point: 4.3094

>AT209107 WP_218506365.1 NZ_CP078142:1940748-1941005 [Salmonella enterica subsp. diarizonae]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQSDPNAEMSEEDREWIDAPAV
GKEIL

Nucleotide

• Length: 258 bp

>AT209107 NZ_CP103850:c2176563-2176270 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA