Detailed information of TA system TA209106

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 817328..817988
• Replicon: chromosome
• Accession: NZ_CP078142
• Organism: Salmonella enterica subsp. diarizonae strain LHICA_D1

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A8E9YGN6
• Locus tag: JMJ85_RS03980
• Protein ID: WP_023249207.1
• Coordinates: 817575..817988 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: S5MU13
• Locus tag: JMJ85_RS03975
• Protein ID: WP_000351186.1
• Coordinates: 817328..817594 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMJ85_RS03955 (813268)	813268..814701	-	1434	WP_079836900.1	6-phospho-beta-glucosidase BglA	-
JMJ85_RS03960 (814860)	814860..815171	+	312	WP_001182976.1	N(4)-acetylcytidine aminohydrolase	-
JMJ85_RS03965 (815335)	815335..815994	+	660	WP_023249205.1	hemolysin III family protein	-
JMJ85_RS03970 (816095)	816095..817075	-	981	WP_023249206.1	tRNA-modifying protein YgfZ	-
JMJ85_RS03975 (817328)	817328..817594	+	267	WP_000351186.1	FAD assembly factor SdhE	Antitoxin
JMJ85_RS03980 (817575)	817575..817988	+	414	WP_023249207.1	protein YgfX	Toxin
JMJ85_RS03985 (818040)	818040..818561	-	522	WP_001055884.1	flavodoxin FldB	-
JMJ85_RS03990 (818674)	818674..819570	+	897	WP_000434302.1	site-specific tyrosine recombinase XerD	-
JMJ85_RS03995 (819594)	819594..820307	+	714	WP_023249209.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
JMJ85_RS04000 (820313)	820313..822049	+	1737	WP_079836898.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16283.31 Da
• Isoelectric Point: 11.4501

>T209106 WP_023249207.1 NZ_CP078142:817575-817988 [Salmonella enterica subsp. diarizonae]
VVLWQSELRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLRSGMVLRLRAESGHHQHLWLAADSMEAAEWRELRRIMLQQPISRQH

Nucleotide

• Length: 414 bp

>T209106 NZ_CP103850:c2156655-2156293 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10550.05 Da
• Isoelectric Point: 6.0783

>AT209106 WP_000351186.1 NZ_CP078142:817328-817594 [Salmonella enterica subsp. diarizonae]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT209106 NZ_CP103850:c2156822-2156652 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A5I0YWH4